PGF

Protein identityUniProt · HPA

UniProt accession

P49763

Gene

PGF

Ensembl

ENSG00000119630

Chromosome

14

Canonical length

221 aa

Protein class

Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins

Subcellular location

Nucleoplasm,Mitochondria,Cytosol

Secretome location

Secreted to blood

Quaternary structure

Homodimer

OverviewNCBI Gene

Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>P49763|PGF
     1  MPVMRLFPCF LQLLAGLALP AVPPQQWALS AGNGSSEVEV VPFQEVWGRS YCRALERLVD
    61  VVSEYPSEVE HMFSPSCVSL LRCTGCCGDE NLHCVPVETA NVTMQLLKIR SGDRPSYVEL
   121  TFSQHVRCEC RHSPGRQSPD MPGDFRADAP SFLPPRRSLP MLFRMEWGCA LTGSQSAVWP
   181  SSPVPEEIPR MHPGRNGKKQ QRKPLREKMK PERCGDAVPR R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PGF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

67 nTPM

Expression across tissuesHPA

ReferencesPubMed · IEDB

Publications for PGF from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.8

gnomAD pLI

0.13

gnomAD missense Z

0.08

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell differentiation
• cell-cell signaling
• induction of positive chemotaxis
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of mast cell chemotaxis
• response to hypoxia
• signal transduction
• sprouting angiogenesis
• vascular endothelial growth factor receptor signaling pathway
• vascular endothelial growth factor signaling pathway

Molecular functions

• chemoattractant activity
• growth factor activity
• heparin binding
• vascular endothelial growth factor receptor binding

Cellular components

• extracellular region
• extracellular space
• membrane

Protein domainsUniProt · Pfam · InterPro

• PDGF/VEGF domain
• Platelet-derived growth factor, conserved site
• Cystine-knot cytokine
• Platelet-derived/Vascular endothelial growth factor
• PDGF/VEGF domain

KeywordsUniProt

• Angiogenesis
• Developmental protein
• Differentiation
• Disulfide bond
• Glycoprotein
• Growth factor
• Heparin-binding
• Mitogen
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of PGF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FLT1