Seroatlas · Human Serome Atlas

TNFAIP8L1

Tumor necrosis factor alpha-induced protein 8-like protein 1

Also known as: MGC17791, TP8L1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVP5
Gene: TNFAIP8L1
Ensembl: ENSG00000185361
Chromosome: 19
Canonical length: 186 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q8WVP5|TNFAIP8L1
     1  MDTFSTKSLA LQAQKKLLSK MASKAVVAVL VDDTSSEVLD ELYRATREFT RSRKEAQKML
    61  KNLVKVALKL GLLLRGDQLG GEELALLRRF RHRARCLAMT AVSFHQVDFT FDRRVLAAGL
   121  LECRDLLHQA VGPHLTAKSH GRINHVFGHL ADCDFLAALY GPAEPYRSHL RRICEGLGRM
   181  LDEGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TNFAIP8L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

liver: 33 nTPM
colon: 29 nTPM
fallopian tube: 22 nTPM
spleen: 17 nTPM
testis: 13 nTPM
cerebral cortex: 13 nTPM

Single-cell type

late spermatids: 1,467 nCPM
early spermatids: 407 nCPM
respiratory ciliated cells: 189 nCPM
fallopian tube ciliated cells: 161 nCPM
endometrial ciliated cells: 123 nCPM
epididymal efferent duct ciliated cells: 110 nCPM

Immune cell

eosinophil: 7 nTPM
non-classical monocyte: 5.1 nTPM
memory B-cell: 3.6 nTPM
intermediate monocyte: 3.3 nTPM
T-reg: 3.3 nTPM
basophil: 3.1 nTPM

Brain region

cerebral cortex: 20 nTPM
hippocampal formation: 20 nTPM
amygdala: 16 nTPM
hypothalamus: 16 nTPM
basal ganglia: 16 nTPM
cerebellum: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0.54
gnomAD missense Z: 1.68
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of TNFAIP8L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FBXW5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TNFAIP8L1 as an antibody target. Whether an autoantibody or antibody against TNFAIP8L1 could matter depends on whether native TNFAIP8L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TNFAIP8L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TNFAIP8L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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