Extracellular matrix structural protein
IPR050751
Definition
This family of proteins is involved in the structural organization and remodeling of the extracellular matrix (ECM). Members of this family play key roles in cell adhesion, migration, and development by interacting with various ECM components, including fibronectin, elastin, and collagen. They contribute to the formation of elastic fibers, basement membranes, and matrix fibers, and are implicated in processes such as blood clotting, tumor suppression, and the regulation of cell shape and adhesion. Some family members are also involved in the activation of growth factor signaling pathways, which can influence cellular proliferation and differentiation. The diverse functions of these proteins reflect their importance in maintaining tissue integrity and facilitating cellular interactions with the ECM.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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