Seroatlas · Human Serome Atlas

CSNK1A1L

Casein kinase I isoform alpha-like

Also known as: KC1AL_HUMAN, MGC33182

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N752
Gene: CSNK1A1L
Ensembl: ENSG00000180138
Chromosome: 13
Canonical length: 337 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and signal transduction. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q8N752|CSNK1A1L
     1  MTNNSGSKAE LVVGGKYKLV RKIGSGSFGD VYLGITTTNG EDVAVKLESQ KVKHPQLLYE
    61  SKLYTILQGG VGIPHMHWYG QEKDNNVLVM DLLGPSLEDL FNFCSRRFTM KTVLMLADQM
   121  ISRIEYVHTK NFLHRDIKPD NFLMGTGRHC NKLFLIDFGL AKKYRDNRTR QHIPYREDKH
   181  LIGTVRYASI NAHLGIEQSR RDDMESLGYV FMYFNRTSLP WQGLRAMTKK QKYEKISEKK
   241  MSTPVEVLCK GFPAEFAMYL NYCRGLRFEE VPDYMYLRQL FRILFRTLNH QYDYTFDWTM
   301  LKQKAAQQAA SSSGQGQQAQ TQTGKQTEKN KNNVKDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSNK1A1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

testis: 3.3 nTPM
bone marrow: 0.5 nTPM
appendix: 0.1 nTPM
lung: 0.1 nTPM
spleen: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

late spermatids: 30 nCPM
late primary spermatocytes: 27 nCPM
early spermatids: 26 nCPM
early primary spermatocytes: 8.3 nCPM
papillary tip epithelial cells: 1.3 nCPM
renal collecting duct intercalated cells: 0.7 nCPM

Immune cell

neutrophil: 7.6 nTPM
basophil: 0.2 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebral cortex: 0.9 nTPM
medulla oblongata: 0.7 nTPM
white matter: 0.7 nTPM
basal ganglia: 0.5 nTPM
hypothalamus: 0.5 nTPM
midbrain: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0.01
gnomAD missense Z: 0.17
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CSNK1A1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CSNK1A1L as an antibody target. Whether an autoantibody or antibody against CSNK1A1L could matter depends on whether native CSNK1A1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CSNK1A1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CSNK1A1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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