UFD1

Protein identityUniProt · HPA

UniProt accession

Q92890

Gene

UFD1

Ensembl

ENSG00000070010

Chromosome

22

Canonical length

307 aa

Protein class

Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q92890|UFD1
     1  MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP SALDQLSRLN
    61  ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ NLLLEEGGLV QVESVNLQVA
   121  TYSKFQPQSP DFLDITNPKA VLENALRNFA CLTTGDVIAI NYNEKIYELR VMETKPDKAV
   181  SIIECDMNVD FDAPLGYKEP ERQVQHEEST EGEADHSGYA GELGFRAFSG SGNRLDGKKK
   241  GVEPSPSPIK PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF VAFSGEGQSL
   301  RKKGRKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UFD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.45

Highest tissue expression

93 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.23

gnomAD pLI

1

DepMap mean gene effect

-1.41

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to misfolded protein
• ERAD pathway
• negative regulation of RIG-I signaling pathway
• negative regulation of type I interferon production
• proteasome-mediated ubiquitin-dependent protein catabolic process
• retrograde protein transport, ER to cytosol
• skeletal system development
• ubiquitin-dependent protein catabolic process

Molecular functions

• cysteine-type deubiquitinase activity
• K48-linked polyubiquitin modification-dependent protein binding
• polyubiquitin modification-dependent protein binding

Cellular components

• cytosol
• nucleoplasm
• nucleus
• UFD1-NPL4 complex
• VCP-NPL4-UFD1 AAA ATPase complex

Protein domainsUniProt · Pfam · InterPro

• Ubiquitin fusion degradation protein UFD1-like
• UFD1-like, Nn domain
• Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1
• Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2
• Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1
• Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2

KeywordsUniProt

• Acetylation
• Cytoplasm
• Nucleus
• Phosphoprotein
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of UFD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• USP13
• ZFAND2B
• FAF1
• NPLOC4
• VCP