Seroatlas · Human Serome Atlas

YTHDF3

YTH domain-containing family protein 3

Also known as: FLJ31657, YTHD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z739
Gene: YTHDF3
Ensembl: ENSG00000185728
Chromosome: 8
Canonical length: 585 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the YTH (YT521-B homology) domain protein family. The YTH domain is common in eukaryotes, is often found in the middle of the protein sequence, and may function in binding to RNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Canonical amino-acid sequenceUniProt

585 residues, UniProt reviewed canonical sequence.

>Q7Z739|YTHDF3
     1  MSATSVDQRP KGQGNKVSVQ NGSIHQKDAV NDDDFEPYLS SQTNQSNSYP PMSDPYMPSY
    61  YAPSIGFPYS LGEAAWSTAG DQPMPYLTTY GQMSNGEHHY IPDGVFSQPG ALGNTPPFLG
   121  QHGFNFFPGN ADFSTWGTSG SQGQSTQSSA YSSSYGYPPS SLGRAITDGQ AGFGNDTLSK
   181  VPGISSIEQG MTGLKIGGDL TAAVTKTVGT ALSSSGMTSI ATNSVPPVSS AAPKPTSWAA
   241  IARKPAKPQP KLKPKGNVGI GGSAVPPPPI KHNMNIGTWD EKGSVVKAPP TQPVLPPQTI
   301  IQQPQPLIQP PPLVQSQLPQ QQPQPPQPQQ QQGPQPQAQP HQVQPQQQQL QNRWVAPRNR
   361  GAGFNQNNGA GSENFGLGVV PVSASPSSVE VHPVLEKLKA INNYNPKDFD WNLKNGRVFI
   421  IKSYSEDDIH RSIKYSIWCS TEHGNKRLDA AYRSLNGKGP LYLLFSVNGS GHFCGVAEMK
   481  SVVDYNAYAG VWSQDKWKGK FEVKWIFVKD VPNNQLRHIR LENNDNKPVT NSRDTQEVPL
   541  EKAKQVLKII ATFKHTTSIF DDFAHYEKRQ EEEEAMRRER NRNKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YTHDF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 86 nTPM
liver: 38 nTPM
tongue: 34 nTPM
skeletal muscle: 32 nTPM
placenta: 28 nTPM
smooth muscle: 27 nTPM

Single-cell type

neutrophils: 864 nCPM
neutrophil progenitors: 407 nCPM
monocytes: 332 nCPM
macrophages: 211 nCPM
endometrial glandular cells: 202 nCPM
monocyte progenitors: 170 nCPM

Immune cell

non-classical monocyte: 48 nTPM
basophil: 41 nTPM
neutrophil: 37 nTPM
intermediate monocyte: 33 nTPM
eosinophil: 31 nTPM
classical monocyte: 29 nTPM

Brain region

choroid plexus: 46 nTPM
cerebellum: 45 nTPM
thalamus: 44 nTPM
cerebral cortex: 43 nTPM
basal ganglia: 40 nTPM
hypothalamus: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 2.66

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YTHDF3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YTHDF3 as an antibody target. Whether an autoantibody or antibody against YTHDF3 could matter depends on whether native YTHDF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YTHDF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YTHDF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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