Seroatlas · Human Serome Atlas

PTDSS2

Phosphatidylserine synthase 2

Also known as: PSS2, PTSS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVG9
Gene
PTDSS2
Ensembl
ENSG00000174915
Chromosome
11
Canonical length
487 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine, a structural membrane phospholipid that functions in cell signaling, blood coagulation, and apoptosis. The encoded enzyme also has a high affinity for docosahexaenoic acid (DHA) and can use it to make DHA-containing phosphatidylserine. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q9BVG9|PTDSS2
     1  MRRGERRDAG GPRPESPVPA GRASLEEPPD GPSAGQATGP GEGRRSTESE VYDDGTNTFF
    61  WRAHTLTVLF ILTCTLGYVT LLEETPQDTA YNTKRGIVAS ILVFLCFGVT QAKDGPFSRP
   121  HPAYWRFWLC VSVVYELFLI FILFQTVQDG RQFLKYVDPK LGVPLPERDY GGNCLIYDPD
   181  NETDPFHNIW DKLDGFVPAH FLGWYLKTLM IRDWWMCMII SVMFEFLEYS LEHQLPNFSE
   241  CWWDHWIMDV LVCNGLGIYC GMKTLEWLSL KTYKWQGLWN IPTYKGKMKR IAFQFTPYSW
   301  VRFEWKPASS LRRWLAVCGI ILVFLLAELN TFYLKFVLWM PPEHYLVLLR LVFFVNVGGV
   361  AMREIYDFMD DPKPHKKLGP QAWLVAAITA TELLIVVKYD PHTLTLSLPF YISQCWTLGS
   421  VLALTWTVWR FFLRDITLRY KETRWQKWQN KDDQGSTVGN GDQHPLGLDE DLLGPGVAEG
   481  EGAPTPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTDSS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
45 nTPM

Expression across tissuesHPA

Tissue

  • testis: 45 nTPM
  • cerebellum: 24 nTPM
  • heart muscle: 24 nTPM
  • spinal cord: 24 nTPM
  • ovary: 21 nTPM
  • adrenal gland: 21 nTPM

Single-cell type

  • late spermatids: 255 nCPM
  • late primary spermatocytes: 80 nCPM
  • early spermatids: 58 nCPM
  • oligodendrocytes: 39 nCPM
  • astrocytes: 36 nCPM
  • early primary spermatocytes: 33 nCPM

Immune cell

  • naive CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.2 nTPM
  • intermediate monocyte: 0.2 nTPM
  • plasmacytoid DC: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM

Brain region

  • white matter: 32 nTPM
  • medulla oblongata: 29 nTPM
  • cerebral cortex: 28 nTPM
  • basal ganglia: 27 nTPM
  • midbrain: 26 nTPM
  • cerebellum: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.57
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTDSS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTDSS2 as an antibody target. Whether an autoantibody or antibody against PTDSS2 could matter depends on whether native PTDSS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTDSS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTDSS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PTDSS2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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