Seroatlas · Human Serome Atlas

CDK10

Cyclin-dependent kinase 10

Also known as: CDK10_HUMAN, PISSLRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15131
Gene
CDK10
Ensembl
ENSG00000185324
Chromosome
16
Canonical length
360 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q15131|CDK10
     1  MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ
    61  TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC
   121  EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA
   181  DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP
   241  GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL
   301  HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • liver: 74 nTPM
  • kidney: 62 nTPM
  • cerebral cortex: 52 nTPM
  • thyroid gland: 51 nTPM
  • pituitary gland: 49 nTPM
  • cervix: 48 nTPM

Single-cell type

  • proximal tubule cells: 103 nCPM
  • tuft cells: 69 nCPM
  • enteric stem cells: 60 nCPM
  • paneth cells: 58 nCPM
  • neuroendocrine cells: 56 nCPM
  • enteric transient amplifying cells: 55 nCPM

Immune cell

  • NK-cell: 20 nTPM
  • intermediate monocyte: 20 nTPM
  • myeloid DC: 18 nTPM
  • non-classical monocyte: 16 nTPM
  • naive CD4 T-cell: 15 nTPM
  • gdT-cell: 15 nTPM

Brain region

  • choroid plexus: 19 nTPM
  • cerebral cortex: 17 nTPM
  • hippocampal formation: 16 nTPM
  • cerebellum: 15 nTPM
  • basal ganglia: 14 nTPM
  • amygdala: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK10.

Disease | AllUniProt

Conditions CDK10 is implicated in, by any mechanism.

Disease | GeneticClinVar

33 pathogenic / likely-pathogenic of 173 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
-0.46
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK10 as an antibody target. Whether an autoantibody or antibody against CDK10 could matter depends on whether native CDK10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDK10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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