Seroatlas · Human Serome Atlas

SFXN5

Sideroflexin-5

Also known as: BBG-TCC, SFXN5_HUMAN, SLC56A5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD22
Gene: SFXN5
Ensembl: ENSG00000144040
Chromosome: 2
Canonical length: 340 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Predicted to enable citrate transmembrane transporter activity. Predicted to be involved in citrate transport and mitochondrial transmembrane transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

340 residues, UniProt reviewed canonical sequence.

>Q8TD22|SFXN5
     1  MADTATTASA AAASAASASS DAPPFQLGKP RFQQTSFYGR FRHFLDIIDP RTLFVTERRL
    61  REAVQLLEDY KHGTLRPGVT NEQLWSAQKI KQAILHPDTN EKIFMPFRMS GYIPFGTPIV
   121  VGLLLPNQTL ASTVFWQWLN QSHNACVNYA NRNATKPSPA SKFIQGYLGA VISAVSIAVG
   181  LNVLVQKANK FTPATRLLIQ RFVPFPAVAS ANICNVVLMR YGELEEGIDV LDSDGNLVGS
   241  SKIAARHALL ETALTRVVLP MPILVLPPIV MSMLEKTALL QARPRLLLPV QSLVCLAAFG
   301  LALPLAISLF PQMSEIETSQ LEPEIAQATS SRTVVYNKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SFXN5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 75 nTPM
amygdala: 74 nTPM
basal ganglia: 67 nTPM
midbrain: 43 nTPM
hippocampal formation: 42 nTPM
liver: 37 nTPM

Single-cell type

bergmann glia: 824 nCPM
astrocytes: 713 nCPM
late spermatids: 246 nCPM
ependymal cells: 194 nCPM
distal convoluted tubule cells: 179 nCPM
myonuclei: 173 nCPM

Immune cell

classical monocyte: 6 nTPM
basophil: 5.3 nTPM
neutrophil: 4.8 nTPM
NK-cell: 4.3 nTPM
eosinophil: 3.5 nTPM
non-classical monocyte: 3.2 nTPM

Brain region

thalamus: 90 nTPM
medulla oblongata: 78 nTPM
amygdala: 77 nTPM
midbrain: 71 nTPM
cerebral cortex: 67 nTPM
hypothalamus: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SFXN5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SFXN5 as an antibody target. Whether an autoantibody or antibody against SFXN5 could matter depends on whether native SFXN5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SFXN5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SFXN5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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