Seroatlas · Human Serome Atlas

ERGIC1

Endoplasmic reticulum-Golgi intermediate compartment protein 1

Also known as: ERGI1_HUMAN, ERGIC-32, ERGIC32, KIAA1181, NET24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969X5
Gene
ERGIC1
Ensembl
ENSG00000113719
Chromosome
5
Canonical length
290 aa
Protein class
Disease related genes, Human disease related genes, Predicted membrane proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a cycling membrane protein which is an endoplasmic reticulum-golgi intermediate compartment (ERGIC) protein which interacts with other members of this protein family to increase their turnover. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q969X5|ERGIC1
     1  MPFDFRRFDI YRKVPKDLTQ PTYTGAIISI CCCLFILFLF LSELTGFITT EVVNELYVDD
    61  PDKDSGGKID VSLNISLPNL HCELVGLDIQ DEMGRHEVGH IDNSMKIPLN NGAGCRFEGQ
   121  FSINKVPGNF HVSTHSATAQ PQNPDMTHVI HKLSFGDTLQ VQNIHGAFNA LGGADRLTSN
   181  PLASHDYILK IVPTVYEDKS GKQRYSYQYT VANKEYVAYS HTGRIIPAIW FRYDLSPITV
   241  KYTERRQPLY RFITTICAII GGTFTVAGIL DSCIFTASEA WKKIQLGKMH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERGIC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
72 nTPM

Expression across tissuesHPA

Tissue

  • liver: 72 nTPM
  • stomach: 57 nTPM
  • adrenal gland: 55 nTPM
  • prostate: 55 nTPM
  • skeletal muscle: 50 nTPM
  • colon: 46 nTPM

Single-cell type

  • neutrophils: 1,219 nCPM
  • prostatic glandular cells: 470 nCPM
  • hepatocytes: 339 nCPM
  • alveolar cells type 1: 337 nCPM
  • monocytes: 332 nCPM
  • goblet cells: 329 nCPM

Immune cell

  • neutrophil: 21 nTPM
  • eosinophil: 14 nTPM
  • non-classical monocyte: 11 nTPM
  • NK-cell: 9.6 nTPM
  • intermediate monocyte: 8.5 nTPM
  • memory B-cell: 8.1 nTPM

Brain region

  • thalamus: 39 nTPM
  • medulla oblongata: 35 nTPM
  • midbrain: 35 nTPM
  • spinal cord: 34 nTPM
  • white matter: 32 nTPM
  • hippocampal formation: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERGIC1.

Disease | AllUniProt

Conditions ERGIC1 is implicated in, by any mechanism.

  • Arthrogryposis multiplex congenita 2, neurogenic type (AMC2) MIM:208100

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 54 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.65
gnomAD missense Z
1.45
DepMap mean gene effect
0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERGIC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERGIC1 as an antibody target. Whether an autoantibody or antibody against ERGIC1 could matter depends on whether native ERGIC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERGIC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERGIC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERGIC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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