Seroatlas · Human Serome Atlas

ERGIC2

Endoplasmic reticulum-Golgi intermediate compartment protein 2

Also known as: ERGI2_HUMAN, Erv41, PTX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96RQ1
Gene
ERGIC2
Ensembl
ENSG00000087502
Chromosome
12
Canonical length
377 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli rim,Golgi apparatus,Vesicles

OverviewNCBI Gene

ERGIC2, or PTX1, is a ubiquitously expressed nuclear protein that is downregulated in prostate carcinoma (Kwok et al., 2001 [PubMed 11445006]).[supplied by OMIM, Aug 2008]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q96RQ1|ERGIC2
     1  MRRLNRKKTL SLVKELDAFP KVPESYVETS ASGGTVSLIA FTTMALLTIM EFSVYQDTWM
    61  KYEYEVDKDF SSKLRINIDI TVAMKCQYVG ADVLDLAETM VASADGLVYE PTVFDLSPQQ
   121  KEWQRMLQLI QSRLQEEHSL QDVIFKSAFK STSTALPPRE DDSSQSPNAC RIHGHLYVNK
   181  VAGNFHITVG KAIPHPRGHA HLAALVNHES YNFSHRIDHL SFGELVPAII NPLDGTEKIA
   241  IDHNQMFQYF ITVVPTKLHT YKISADTHQF SVTERERIIN HAAGSHGVSG IFMKYDLSSL
   301  MVTVTEEHMP FWQFFVRLCG IVGGIFSTTG MLHGIGKFIV EIICCRFRLG SYKPVNSVPF
   361  EDGHTDNHLP LLENNTH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERGIC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • testis: 54 nTPM
  • placenta: 50 nTPM
  • heart muscle: 49 nTPM
  • epididymis: 47 nTPM
  • urinary bladder: 47 nTPM
  • salivary gland: 46 nTPM

Single-cell type

  • early spermatids: 393 nCPM
  • late primary spermatocytes: 282 nCPM
  • esophageal apical cells: 229 nCPM
  • plasma cells: 207 nCPM
  • syncytiotrophoblasts: 189 nCPM
  • esophageal suprabasal cells: 163 nCPM

Immune cell

  • neutrophil: 185 nTPM
  • T-reg: 132 nTPM
  • plasmacytoid DC: 121 nTPM
  • memory CD4 T-cell: 108 nTPM
  • naive CD4 T-cell: 107 nTPM
  • MAIT T-cell: 103 nTPM

Brain region

  • white matter: 57 nTPM
  • hypothalamus: 41 nTPM
  • spinal cord: 40 nTPM
  • medulla oblongata: 40 nTPM
  • cerebellum: 39 nTPM
  • cerebral cortex: 38 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERGIC2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.01
gnomAD missense Z
1.07
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERGIC2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERGIC2 as an antibody target. Whether an autoantibody or antibody against ERGIC2 could matter depends on whether native ERGIC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERGIC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ERGIC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERGIC2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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