Seroatlas · Human Serome Atlas

ZNF398

Zinc finger protein 398

Also known as: KIAA1339, P51, P71, ZER6, ZN398_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD17
Gene: ZNF398
Ensembl: ENSG00000197024
Chromosome: 7
Canonical length: 642 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

642 residues, UniProt reviewed canonical sequence.

>Q8TD17|ZNF398
     1  MAEAAPAPTS EWDSECLTSL QPLPLPTPPA ANEAHLQTAA ISLWTVVAAV QAIERKVEIH
    61  SRRLLHLEGR TGTAEKKLAS CEKTVTELGN QLEGKWAVLG TLLQEYGLLQ RRLENLENLL
   121  RNRNFWILRL PPGIKGDIPK VPVAFDDVSI YFSTPEWEKL EEWQKELYKN IMKGNYESLI
   181  SMDYAINQPD VLSQIQPEGE HNTEDQAGPE ESEIPTDPSE EPGISTSDIL SWIKQEEEPQ
   241  VGAPPESKES DVYKSTYADE ELVIKAEGLA RSSLCPEVPV PFSSPPAAAK DAFSDVAFKS
   301  QQSTSMTPFG RPATDLPEAS EGQVTFTQLG SYPLPPPVGE QVFSCHHCGK NLSQDMLLTH
   361  QCSHATEHPL PCAQCPKHFT PQADLSSTSQ DHASETPPTC PHCARTFTHP SRLTYHLRVH
   421  NSTERPFPCP DCPKRFADQA RLTSHRRAHA SERPFRCAQC GRSFSLKISL LLHQRGHAQE
   481  RPFSCPQCGI DFNGHSALIR HQMIHTGERP YPCTDCSKSF MRKEHLLNHR RLHTGERPFS
   541  CPHCGKSFIR KHHLMKHQRI HTGERPYPCS YCGRSFRYKQ TLKDHLRSGH NGGCGGDSDP
   601  SGQPPNPPGP LITGLETSGL GVNTEGLETN QWYGEGSGGG VL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF398 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

testis: 7.9 nTPM
bone marrow: 7.2 nTPM
retina: 7 nTPM
skin: 6.2 nTPM
esophagus: 6 nTPM
tonsil: 5.2 nTPM

Single-cell type

neutrophil progenitors: 86 nCPM
adrenal medulla cells: 75 nCPM
urothelial cells: 72 nCPM
early primary spermatocytes: 72 nCPM
esophageal apical cells: 67 nCPM
myonuclei: 65 nCPM

Immune cell

basophil: 2.4 nTPM
eosinophil: 2.4 nTPM
MAIT T-cell: 1.4 nTPM
naive CD8 T-cell: 1.3 nTPM
memory CD8 T-cell: 1.2 nTPM
naive CD4 T-cell: 1.2 nTPM

Brain region

cerebellum: 28 nTPM
cerebral cortex: 21 nTPM
white matter: 19 nTPM
hypothalamus: 19 nTPM
basal ganglia: 18 nTPM
hippocampal formation: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.15
gnomAD missense Z: 1.07
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF398 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF398 as an antibody target. Whether an autoantibody or antibody against ZNF398 could matter depends on whether native ZNF398 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF398 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF398 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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