Engulfment and cell motility domain-containing protein
IPR050868
Definition
This family of proteins is involved in cellular processes related to the cytoskeleton, including phagocytosis of apoptotic cells and cell motility. Members of this family act in concert with other proteins such as DOCK1 and CRK to facilitate these processes. Some proteins within this family are proposed to activate Rac Rho small GTPases, potentially enhancing the guanine nucleotide exchange factor (GEF) activity of their partners. Additionally, certain members function as GTPase-activating proteins (GAPs) for the ARL2 GTPase and other related factors, but not for GTPases outside the Arf family. This indicates a role in modulating the activity of GTPases involved in various signaling pathways. Furthermore, some proteins in this family are implicated in regulating antiviral responses and maintaining proper cell shape during phagocytosis and chemotaxis by modulating actin polymerization.
6 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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