Dedicator of cytokinesis, N-terminal domain

Definition

This domain is found near to the N terminus of some dedicator of cytokinesis (DOCK) proteins, between the variant SH3 domain and the C2 domain PMID:32651375. This is an α-helical region that mediates interactions with ELMO subunits and provides a major site for interactions between the SH3 and ARM domains of these proteins PMID:32651375. Dedicator of cytokinesis (DOCK) proteins function as guanine nucleotide exchange factors (GEFs) that activate small GTPases by exchanging bound GDP for free GTP, thus converting them into their active GTP-bound form. These proteins are involved in various cellular processes, including cytoskeletal rearrangements, cell migration, phagocytosis of apoptotic cells, and regulation of adherens junctions between cells. Some family members may also play a role in disease processes such as Alzheimer's disease by interacting with presenilin proteins and affecting Tau phosphorylation. DOCK proteins are characterised by the presence of a conserved DOCKER domain, which is necessary for their GEF activity and interaction with small GTPases like RAC1 and RAC2.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• DOCK1
• DOCK2
• DOCK3
• DOCK4
• DOCK5