APOO

Protein identityUniProt · HPA

UniProt accession

Q9BUR5

Gene

APOO

Ensembl

ENSG00000184831

Chromosome

X

Canonical length

198 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters

Subcellular location

Mitochondria,Cytosol

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9BUR5|APOO
     1  MFKVIQRSVG PASLSLLTFK VYAAPKKDSP PKNSVKVDEL SLYSVPEGQS KYVEEARSQL
    61  EESISQLRHY CEPYTTWCQE TYSQTKPKMQ SLVQWGLDSY DYLQNAPPGF FPRLGVIGFA
   121  GLIGLLLARG SKIKKLVYPP GFMGLAASLY YPQQAIVFAQ VSGERLYDWG LRGYIVIEDL
   181  WKENFQKPGN VKNSPGTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.55

Highest tissue expression

103 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about APOO.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 114 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cognitive impairment and autistic features
• X-­linked recessive mitochondrial myopathy
• Lactic acidosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.55

gnomAD pLI

0.6

gnomAD missense Z

-0.04

DepMap mean gene effect

0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cristae formation
• inner mitochondrial membrane organization
• lipid transport

Cellular components

• cytosol
• endoplasmic reticulum membrane
• extracellular region
• extracellular space
• Golgi membrane
• high-density lipoprotein particle
• low-density lipoprotein particle
• MIB complex
• MICOS complex
• mitochondrial crista junction
• mitochondrial inner membrane
• mitochondrion
• SAM complex
• very-low-density lipoprotein particle

Protein domainsUniProt · Pfam · InterPro

• MICOS complex subunit MIC26/MIC27
• MICOS complex subunit MIC26/MIC27, animal
• Apolipoprotein O

KeywordsUniProt

• Endoplasmic reticulum
• Glycoprotein
• Golgi apparatus
• HDL
• LDL
• Lipid transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Proteoglycan
• Secreted
• Signal
• Transmembrane
• Transmembrane helix
• Transport
• VLDL

InteractionsUniProt · HPA

Protein binding partners of APOO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• DNAJC11