Seroatlas · Human Serome Atlas

ARMC1

Armadillo repeat-containing protein 1

Also known as: Arcp, ARMC1_HUMAN, FLJ10511

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVT9
Gene: ARMC1
Ensembl: ENSG00000104442
Chromosome: 8
Canonical length: 282 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable metal ion binding activity. Involved in intracellular distribution of mitochondria. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

282 residues, UniProt reviewed canonical sequence.

>Q9NVT9|ARMC1
     1  MNSSTSTMSE EPDALSVVNQ LRDLAADPLN RRAIVQDQGC LPGLILFMDH PNPPVVHSAL
    61  LALRYLAECR ANREKMKGEL GMMLSLQNVI QKTTTPGETK LLASEIYDIL QSSNMADGDS
   121  FNEMNSRRRK AQFFLGTTNK RAKTVVLHID GLDDTSRRNL CEEALLKIKG VISFTFQMAV
   181  QRCVVRIRSD LKAEALASAI ASTKVMKAQQ VVKSESGEEM LVPFQDTPVE VEQNTELPDY
   241  LPEDESPTKE QDKAVSRVGS HPEGGASWLS TAANFLSRSF YW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

tongue: 23 nTPM
liver: 22 nTPM
thymus: 21 nTPM
kidney: 21 nTPM
cerebellum: 21 nTPM
spinal cord: 20 nTPM

Single-cell type

oocytes: 129 nCPM
erythrocyte progenitors: 84 nCPM
thymic myoid cells: 65 nCPM
extravillous trophoblasts: 57 nCPM
oligodendrocytes: 55 nCPM
myonuclei: 49 nCPM

Immune cell

basophil: 36 nTPM
NK-cell: 12 nTPM
MAIT T-cell: 11 nTPM
T-reg: 11 nTPM
memory CD8 T-cell: 10 nTPM
naive CD8 T-cell: 10 nTPM

Brain region

white matter: 42 nTPM
basal ganglia: 39 nTPM
hypothalamus: 36 nTPM
cerebral cortex: 34 nTPM
cerebellum: 34 nTPM
midbrain: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.76
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular distribution of mitochondria

Molecular functions

metal ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo
Armadillo-like helical
Armadillo-type fold
Heavy metal-associated domain superfamily
Armadillo/beta-catenin-like repeat
Armadillo repeat-containing protein 1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC1 as an antibody target. Whether an autoantibody or antibody against ARMC1 could matter depends on whether native ARMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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