Seroatlas · Human Serome Atlas

SAMM50

Sorting and assembly machinery component 50 homolog

Also known as: CGI-51, OMP85, SAM50, SAM50_HUMAN, TOB55, TRG-3, YNL026W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y512
Gene
SAMM50
Ensembl
ENSG00000100347
Chromosome
22
Canonical length
469 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a component of the Sorting and Assembly Machinery (SAM) of the mitochondrial outer membrane. The Sam complex functions in the assembly of beta-barrel proteins into the outer mitochondrial membrane.[provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

469 residues, UniProt reviewed canonical sequence.

>Q9Y512|SAMM50
     1  MGTVHARSLE PLPSSGPDFG GLGEEAEFVE VEPEAKQEIL ENKDVVVQHV HFDGLGRTKD
    61  DIIICEIGDV FKAKNLIEVM RKSHEAREKL LRLGIFRQVD VLIDTCQGDD ALPNGLDVTF
   121  EVTELRRLTG SYNTMVGNNE GSMVLGLKLP NLLGRAEKVT FQFSYGTKET SYGLSFFKPR
   181  PGNFERNFSV NLYKVTGQFP WSSLRETDRG MSAEYSFPIW KTSHTVKWEG VWRELGCLSR
   241  TASFAVRKES GHSLKSSLSH AMVIDSRNSS ILPRRGALLK VNQELAGYTG GDVSFIKEDF
   301  ELQLNKQLIF DSVFSASFWG GMLVPIGDKP SSIADRFYLG GPTSIRGFSM HSIGPQSEGD
   361  YLGGEAYWAG GLHLYTPLPF RPGQGGFGEL FRTHFFLNAG NLCNLNYGEG PKAHIRKLAE
   421  CIRWSYGAGI VLRLGNIARL ELNYCVPMGV QTGDRICDGV QFGAGIRFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SAMM50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
225 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 225 nTPM
  • tongue: 165 nTPM
  • parathyroid gland: 108 nTPM
  • heart muscle: 63 nTPM
  • adrenal gland: 49 nTPM
  • duodenum: 48 nTPM

Single-cell type

  • parietal cells: 133 nCPM
  • esophageal basal cells: 93 nCPM
  • oocytes: 88 nCPM
  • thymic myoid cells: 82 nCPM
  • late primary spermatocytes: 80 nCPM
  • erythrocyte progenitors: 77 nCPM

Immune cell

  • myeloid DC: 68 nTPM
  • MAIT T-cell: 56 nTPM
  • memory B-cell: 55 nTPM
  • naive B-cell: 51 nTPM
  • basophil: 48 nTPM
  • eosinophil: 47 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • pons: 31 nTPM
  • cerebellum: 30 nTPM
  • medulla oblongata: 30 nTPM
  • hypothalamus: 29 nTPM
  • midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.92
DepMap mean gene effect
-0.58
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Bacterial surface antigen (D15)
  • POTRA domain
  • Surface antigen D15-like
  • Omp85 superfamily domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SAMM50 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SAMM50 as an antibody target. Whether an autoantibody or antibody against SAMM50 could matter depends on whether native SAMM50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SAMM50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SAMM50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SAMM50. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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