Seroatlas · Human Serome Atlas

RTF2

Replication termination factor 2

Also known as: C20orf43, CDAO5, HSPC164, RTF2_HUMAN, RTFDC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BY42
Gene: RTF2
Ensembl: ENSG00000022277
Chromosome: 20
Canonical length: 306 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9BY42|RTF2
     1  MGCDGGTIPK RHELVKGPKK VEKVDKDAEL VAQWNYCTLS QEILRRPIVA CELGRLYNKD
    61  AVIEFLLDKS AEKALGKAAS HIKSIKNVTE LKLSDNPAWE GDKGNTKGDK HDDLQRARFI
   121  CPVVGLEMNG RHRFCFLRCC GCVFSERALK EIKAEVCHTC GAAFQEDDVI MLNGTKEDVD
   181  VLKTRMEERR LRAKLEKKTK KPKAAESVSK PDVSEEAPGP SKVKTGKPEE ASLDSREKKT
   241  NLAPKSTAMN ESSSGKAGKP PCGATKRSIA DSEESEAYKS LFTTHSSAKR SKEESAHWVT
   301  HTSYCF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RTF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 170 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 170 nTPM
spinal cord: 139 nTPM
bone marrow: 121 nTPM
midbrain: 114 nTPM
tongue: 104 nTPM
basal ganglia: 99 nTPM

Single-cell type

neutrophils: 563 nCPM
neutrophil progenitors: 272 nCPM
somatotrophs: 114 nCPM
mast cells: 89 nCPM
monocytes: 86 nCPM
megakaryocytes: 80 nCPM

Immune cell

neutrophil: 583 nTPM
eosinophil: 564 nTPM
basophil: 311 nTPM
total PBMC: 254 nTPM
myeloid DC: 224 nTPM
classical monocyte: 206 nTPM

Brain region

white matter: 120 nTPM
cerebellum: 113 nTPM
medulla oblongata: 107 nTPM
basal ganglia: 101 nTPM
spinal cord: 101 nTPM
midbrain: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
DepMap mean gene effect: -1.37
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Replication termination factor 2
Replication termination factor 2, RING-finger
Rtf2 RING-finger

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RTF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RTF2 as an antibody target. Whether an autoantibody or antibody against RTF2 could matter depends on whether native RTF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RTF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RTF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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