Seroatlas · Human Serome Atlas

CHCHD6

MICOS complex subunit MIC25

Also known as: CHCM1, MGC13016, Mic25, MIC25_HUMAN, MICOS25, PPP1R23

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRQ6
Gene: CHCHD6
Ensembl: ENSG00000159685
Chromosome: 3
Canonical length: 235 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria,Cytosol

OverviewNCBI Gene

Involved in DNA damage response and cristae formation. Located in cytosol and mitochondrial inner membrane. Part of MICOS complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q9BRQ6|CHCHD6
     1  MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL
    61  RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL
   121  PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA
   181  ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CHCHD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 62 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 62 nTPM
cerebral cortex: 55 nTPM
testis: 51 nTPM
amygdala: 46 nTPM
basal ganglia: 41 nTPM
hypothalamus: 34 nTPM

Single-cell type

melanocytes: 455 nCPM
hofbauer cells: 388 nCPM
late primary spermatocytes: 256 nCPM
oocytes: 226 nCPM
respiratory ciliated cells: 165 nCPM
late spermatids: 164 nCPM

Immune cell

naive B-cell: 12 nTPM
naive CD8 T-cell: 11 nTPM
memory CD4 T-cell: 10 nTPM
T-reg: 10 nTPM
naive CD4 T-cell: 9.4 nTPM
MAIT T-cell: 8.8 nTPM

Brain region

hippocampal formation: 52 nTPM
cerebral cortex: 45 nTPM
basal ganglia: 30 nTPM
hypothalamus: 26 nTPM
white matter: 24 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -0.62
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CHCHD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CHCHD6 as an antibody target. Whether an autoantibody or antibody against CHCHD6 could matter depends on whether native CHCHD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CHCHD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CHCHD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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