Seroatlas · Human Serome Atlas

BOC

Brother of CDO

Also known as: BOC_HUMAN, Boi, CDON2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWV1
Gene: BOC
Ensembl: ENSG00000144857
Chromosome: 3
Canonical length: 1114 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

1114 residues, UniProt reviewed canonical sequence.

>Q9BWV1|BOC
     1  MLRGTMTAWR GMRPEVTLAC LLLATAGCFA DLNEVPQVTV QPASTVQKPG GTVILGCVVE
    61  PPRMNVTWRL NGKELNGSDD ALGVLITHGT LVITALNNHT VGRYQCVARM PAGAVASVPA
   121  TVTLANLQDF KLDVQHVIEV DEGNTAVIAC HLPESHPKAQ VRYSVKQEWL EASRGNYLIM
   181  PSGNLQIVNA SQEDEGMYKC AAYNPVTQEV KTSGSSDRLR VRRSTAEAAR IIYPPEAQTI
   241  IVTKGQSLIL ECVASGIPPP RVTWAKDGSS VTGYNKTRFL LSNLLIDTTS EEDSGTYRCM
   301  ADNGVGQPGA AVILYNVQVF EPPEVTMELS QLVIPWGQSA KLTCEVRGNP PPSVLWLRNA
   361  VPLISSQRLR LSRRALRVLS MGPEDEGVYQ CMAENEVGSA HAVVQLRTSR PSITPRLWQD
   421  AELATGTPPV SPSKLGNPEQ MLRGQPALPR PPTSVGPASP QCPGEKGQGA PAEAPIILSS
   481  PRTSKTDSYE LVWRPRHEGS GRAPILYYVV KHRKVTNSSD DWTISGIPAN QHRLTLTRLD
   541  PGSLYEVEMA AYNCAGEGQT AMVTFRTGRR PKPEIMASKE QQIQRDDPGA SPQSSSQPDH
   601  GRLSPPEAPD RPTISTASET SVYVTWIPRG NGGFPIQSFR VEYKKLKKVG DWILATSAIP
   661  PSRLSVEITG LEKGTSYKFR VRALNMLGES EPSAPSRPYV VSGYSGRVYE RPVAGPYITF
   721  TDAVNETTIM LKWMYIPASN NNTPIHGFYI YYRPTDSDND SDYKKDMVEG DKYWHSISHL
   781  QPETSYDIKM QCFNEGGESE FSNVMICETK ARKSSGQPGR LPPPTLAPPQ PPLPETIERP
   841  VGTGAMVARS SDLPYLIVGV VLGSIVLIIV TFIPFCLWRA WSKQKHTTDL GFPRSALPPS
   901  CPYTMVPLGG LPGHQASGQP YLSGISGRAC ANGIHMNRGC PSAAVGYPGM KPQQHCPGEL
   961  QQQSDTSSLL RQTHLGNGYD PQSHQITRGP KSSPDEGSFL YTLPDDSTHQ LLQPHHDCCQ
  1021  RQEQPAAVGQ SGVRRAPDSP VLEAVWDPPF HSGPPCCLGL VPVEEVDSPD SCQVSGGDWC
  1081  PQHPVGAYVG QEPGMQLSPG PLVRVSFETP PLTI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 43 nTPM
skin: 33 nTPM
ovary: 31 nTPM
smooth muscle: 30 nTPM
colon: 29 nTPM
esophagus: 23 nTPM

Single-cell type

pituicytes/fscs: 646 nCPM
pituitary stem cells: 436 nCPM
fibro-adipogenic progenitors: 394 nCPM
retinal pigment epithelial cells: 226 nCPM
leydig cells: 187 nCPM
ependymal cells: 186 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 112 nTPM
choroid plexus: 70 nTPM
spinal cord: 70 nTPM
midbrain: 66 nTPM
thalamus: 57 nTPM
white matter: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0
gnomAD missense Z: 1.19
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Immunoglobulin subtype 2
Immunoglobulin domain subtype
Fibronectin type III
Immunoglobulin-like domain
Immunoglobulin I-set
Immunoglobulin-like fold
Fibronectin type III superfamily
Immunoglobulin-like domain superfamily
Fibronectin type III domain
Immunoglobulin I-set domain
Immunoglobulin domain
Unstructured linking region I-set and fnIII on Brother of CDO

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOC as an antibody target. Whether an autoantibody or antibody against BOC could matter depends on whether native BOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOC is annotated at the cell surface, where native BOC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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