THBS2

Protein identityUniProt · HPA

UniProt accession

P35442

Gene

THBS2

Ensembl

ENSG00000186340

Chromosome

6

Canonical length

1172 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins

Subcellular location

Plasma membrane,Centrosome,Cytosol

Secretome location

Secreted to extracellular matrix

Quaternary structure

Homotrimer

OverviewNCBI Gene

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1172 residues, UniProt reviewed canonical sequence.

>P35442|THBS2
     1  MVWRLVLLAL WVWPSTQAGH QDKDTTFDLF SISNINRKTI GAKQFRGPDP GVPAYRFVRF
    61  DYIPPVNADD LSKITKIMRQ KEGFFLTAQL KQDGKSRGTL LALEGPGLSQ RQFEIVSNGP
   121  ADTLDLTYWI DGTRHVVSLE DVGLADSQWK NVTVQVAGET YSLHVGCDLI DSFALDEPFY
   181  EHLQAEKSRM YVAKGSARES HFRGLLQNVH LVFENSVEDI LSKKGCQQGQ GAEINAISEN
   241  TETLRLGPHV TTEYVGPSSE RRPEVCERSC EELGNMVQEL SGLHVLVNQL SENLKRVSND
   301  NQFLWELIGG PPKTRNMSAC WQDGRFFAEN ETWVVDSCTT CTCKKFKTIC HQITCPPATC
   361  ASPSFVEGEC CPSCLHSVDG EEGWSPWAEW TQCSVTCGSG TQQRGRSCDV TSNTCLGPSI
   421  QTRACSLSKC DTRIRQDGGW SHWSPWSSCS VTCGVGNITR IRLCNSPVPQ MGGKNCKGSG
   481  RETKACQGAP CPIDGRWSPW SPWSACTVTC AGGIRERTRV CNSPEPQYGG KACVGDVQER
   541  QMCNKRSCPV DGCLSNPCFP GAQCSSFPDG SWSCGSCPVG FLGNGTHCED LDECALVPDI
   601  CFSTSKVPRC VNTQPGFHCL PCPPRYRGNQ PVGVGLEAAK TEKQVCEPEN PCKDKTHNCH
   661  KHAECIYLGH FSDPMYKCEC QTGYAGDGLI CGEDSDLDGW PNLNLVCATN ATYHCIKDNC
   721  PHLPNSGQED FDKDGIGDAC DDDDDNDGVT DEKDNCQLLF NPRQADYDKD EVGDRCDNCP
   781  YVHNPAQIDT DNNGEGDACS VDIDGDDVFN ERDNCPYVYN TDQRDTDGDG VGDHCDNCPL
   841  VHNPDQTDVD NDLVGDQCDN NEDIDDDGHQ NNQDNCPYIS NANQADHDRD GQGDACDPDD
   901  DNDGVPDDRD NCRLVFNPDQ EDLDGDGRGD ICKDDFDNDN IPDIDDVCPE NNAISETDFR
   961  NFQMVPLDPK GTTQIDPNWV IRHQGKELVQ TANSDPGIAV GFDEFGSVDF SGTFYVNTDR
  1021  DDDYAGFVFG YQSSSRFYVV MWKQVTQTYW EDQPTRAYGY SGVSLKVVNS TTGTGEHLRN
  1081  ALWHTGNTPG QVRTLWHDPR NIGWKDYTAY RWHLTHRPKT GYIRVLVHEG KQVMADSGPI
  1141  YDQTYAGGRL GLFVFSQEMV YFSDLKYECR DI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THBS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

160 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about THBS2.

Disease | AllUniProt

Conditions THBS2 is implicated in, by any mechanism.

• Intervertebral disc disease (IDD) MIM:603932
• Ehlers-Danlos syndrome, classic-like, 3 (EDSCLL3) MIM:620865

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 234 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Ehlers-Danlos syndrome
• Ehlers-Danlos syndrome, classic-like, 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.35

gnomAD pLI

0.56

gnomAD missense Z

2.21

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• negative regulation of angiogenesis
• positive regulation of synapse assembly

Molecular functions

• calcium ion binding
• heparin binding

Cellular components

• basement membrane
• extracellular matrix
• extracellular region
• platelet alpha granule

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain
• Thrombospondin type-1 (TSP1) repeat
• VWFC domain
• EGF-like calcium-binding domain
• Thrombospondin, type 3-like repeat
• Thrombospondin, C-terminal
• Concanavalin A-like lectin/glucanase domain superfamily
• Thrombospondin, type 3 repeat
• NELL2-like, EGF domain
• TSP type-3 repeat
• Thrombospondin type-1 repeat superfamily
• Thrombospondin-like, N-terminal domain
• Thrombospondin type 1 domain
• von Willebrand factor type C domain
• Thrombospondin type 3 repeat
• Thrombospondin C-terminal region
• EGF domain

KeywordsUniProt

• Calcium
• Cell adhesion
• Disulfide bond
• EGF-like domain
• Ehlers-Danlos syndrome
• Glycoprotein
• Heparin-binding
• Repeat
• Signal

InteractionsUniProt · HPA

Protein binding partners of THBS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• HRG
• CD36