TLR6

Protein identityUniProt · HPA

UniProt accession

Q9Y2C9

Gene

TLR6

Ensembl

ENSG00000174130

Chromosome

4

Canonical length

796 aa

Protein class

CD markers, Predicted membrane proteins

Subcellular location

Endoplasmic reticulum

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>Q9Y2C9|TLR6
     1  MTKDKEPIVK SFHFVCLMII IVGTRIQFSD GNEFAVDKSK RGLIHVPKDL PLKTKVLDMS
    61  QNYIAELQVS DMSFLSELTV LRLSHNRIQL LDLSVFKFNQ DLEYLDLSHN QLQKISCHPI
   121  VSFRHLDLSF NDFKALPICK EFGNLSQLNF LGLSAMKLQK LDLLPIAHLH LSYILLDLRN
   181  YYIKENETES LQILNAKTLH LVFHPTSLFA IQVNISVNTL GCLQLTNIKL NDDNCQVFIK
   241  FLSELTRGST LLNFTLNHIE TTWKCLVRVF QFLWPKPVEY LNIYNLTIIE SIREEDFTYS
   301  KTTLKALTIE HITNQVFLFS QTALYTVFSE MNIMMLTISD TPFIHMLCPH APSTFKFLNF
   361  TQNVFTDSIF EKCSTLVKLE TLILQKNGLK DLFKVGLMTK DMPSLEILDV SWNSLESGRH
   421  KENCTWVESI VVLNLSSNML TDSVFRCLPP RIKVLDLHSN KIKSVPKQVV KLEALQELNV
   481  AFNSLTDLPG CGSFSSLSVL IIDHNSVSHP SADFFQSCQK MRSIKAGDNP FQCTCELREF
   541  VKNIDQVSSE VLEGWPDSYK CDYPESYRGS PLKDFHMSEL SCNITLLIVT IGATMLVLAV
   601  TVTSLCIYLD LPWYLRMVCQ WTQTRRRARN IPLEELQRNL QFHAFISYSE HDSAWVKSEL
   661  VPYLEKEDIQ ICLHERNFVP GKSIVENIIN CIEKSYKSIF VLSPNFVQSE WCHYELYFAH
   721  HNLFHEGSNN LILILLEPIP QNSIPNKYHK LKALMTQRTY LQWPKEKSKR GLFWANIRAA
   781  FNMKLTLVTE NNDVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TLR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

11 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.85

gnomAD pLI

0

gnomAD missense Z

0.94

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of NF-kappaB-inducing kinase activity
• cellular response to amyloid-beta
• cellular response to diacyl bacterial lipopeptide
• cellular response to oxidised low-density lipoprotein particle stimulus
• defense response to bacterium
• detection of diacyl bacterial lipopeptide
• immune response
• inflammatory response
• innate immune response
• microglial cell activation
• MyD88-dependent toll-like receptor signaling pathway
• negative regulation of interleukin-8 production
• negative regulation of toll-like receptor 2 signaling pathway
• negative regulation of tumor necrosis factor production
• nitric oxide metabolic process
• positive regulation of canonical NF-kappaB signal transduction
• positive regulation of cytokine production involved in inflammatory response
• positive regulation of extrinsic apoptotic signaling pathway
• positive regulation of gene expression
• positive regulation of inflammatory response
• positive regulation of interleukin-1 beta production
• positive regulation of interleukin-6 production
• positive regulation of JUN kinase activity
• positive regulation of macrophage activation
• positive regulation of nitric oxide biosynthetic process
• positive regulation of NLRP3 inflammasome complex assembly
• positive regulation of reactive oxygen species biosynthetic process
• signal transduction
• toll-like receptor signaling pathway
• toll-like receptor TLR6:TLR2 signaling pathway
• TRIF-dependent toll-like receptor signaling pathway

Molecular functions

• amyloid-beta binding
• identical protein binding
• lipopeptide binding
• protein heterodimerization activity
• signaling receptor activity
• signaling receptor binding
• Toll-like receptor 2 binding
• transmembrane signaling receptor activity
• diacyl lipopeptide binding

Cellular components

• Golgi apparatus
• membrane raft
• phagocytic vesicle membrane
• plasma membrane
• receptor complex
• Toll-like receptor 2-Toll-like receptor 6 protein complex

Protein domainsUniProt · Pfam · InterPro

• Toll/interleukin-1 receptor homology (TIR) domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Toll-like receptor
• Leucine-rich repeat domain superfamily
• Toll/interleukin-1 receptor homology (TIR) domain superfamily
• Leucine rich repeat C-terminal domain
• TIR domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Cytoplasmic vesicle
• Disulfide bond
• Glycoprotein
• Golgi apparatus
• Immunity
• Inflammatory response
• Innate immunity
• Leucine-rich repeat
• Membrane
• NAD
• Receptor
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TLR6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CD14
• CD36
• TLR2