RRM2

Protein identityUniProt · HPA

UniProt accession

P31350

Gene

RRM2

Ensembl

ENSG00000171848

Chromosome

2

Canonical length

389 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>P31350|RRM2
     1  MLSLRVPLAP ITDPQQLQLS PLKGLSLVDK ENTPPALSGT RVLASKTARR IFQEPTEPKT
    61  KAAAPGVEDE PLLRENPRRF VIFPIEYHDI WQMYKKAEAS FWTAEEVDLS KDIQHWESLK
   121  PEERYFISHV LAFFAASDGI VNENLVERFS QEVQITEARC FYGFQIAMEN IHSEMYSLLI
   181  DTYIKDPKER EFLFNAIETM PCVKKKADWA LRWIGDKEAT YGERVVAFAA VEGIFFSGSF
   241  ASIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFKHL VHKPSEERVR EIIINAVRIE
   301  QEFLTEALPV KLIGMNCTLM KQYIEFVADR LMLELGFSKV FRVENPFDFM ENISLEGKTN
   361  FFEKRVGEYQ RMGVMSSPTE NSFTLDADF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RRM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

54 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0.75

gnomAD missense Z

2.34

DepMap mean gene effect

-2.34

DepMap dependency class

pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• 2'-deoxyribonucleotide biosynthetic process
• blastocyst development
• deoxyribonucleotide biosynthetic process
• DNA repair
• positive regulation of G1/S transition of mitotic cell cycle
• protein heterotetramerization
• ribonucleoside diphosphate metabolic process

Molecular functions

• ferric iron binding
• protein homodimerization activity
• ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

Cellular components

• cytosol
• nucleoplasm
• nucleus
• ribonucleoside-diphosphate reductase complex

Protein domainsUniProt · Pfam · InterPro

• Ribonucleotide reductase small subunit family
• Ferritin-like superfamily
• Ribonucleotide reductase-like
• Ribonucleotide reductase small subunit, acitve site
• Ribonucleotide reductase small subunit
• Ribonucleotide reductase, small chain

KeywordsUniProt

• Cytoplasm
• Deoxyribonucleotide synthesis
• Iron
• Metal-binding
• Nucleus
• Oxidoreductase
• Phosphoprotein
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of RRM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CCNF
• FZR1
• HSPA8
• RRM1