Seroatlas · Human Serome Atlas

ZNF652

Zinc finger protein 652

Also known as: KIAA0924, ZN652_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2D9
Gene: ZNF652
Ensembl: ENSG00000198740
Chromosome: 17
Canonical length: 606 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q9Y2D9|ZNF652
     1  MSHTASSCQE LVENCAVHVA GMAQEDSRRG QVPSSFYHGA NQELDLSTKV YKRESGSPYS
    61  VLVDTKMSKP HLHETEEQPY FRETRAVSDV HAVKEDRENS DDTEEEEEEV SYKREQIIVE
   121  VNLNNQTLNV SKGEKGVSSQ SKETPVLKTS SEEEEEESEE EATDDSNDYG ENEKQKKKEK
   181  IVEKVSVTQR RTRRAASVAA ATTSPTPRTT RGRRKSVEPP KRKKRATKEP KAPVQKAKCE
   241  EKETLTCEKC PRVFNTRWYL EKHMNVTHRR MQICDKCGKK FVLESELSLH QQTDCEKNIQ
   301  CVSCNKSFKK LWSLHEHIKI VHGYAEKKFS CEICEKKFYT MAHVRKHMVA HTKDMPFTCE
   361  TCGKSFKRSM SLKVHSLQHS GEKPFRCENC DERFQYKYQL RSHMSIHIGH KQFMCQWCGK
   421  DFNMKQYFDE HMKTHTGEKP FICEICGKSF TSRPNMKRHR RTHTGEKPYP CDVCGQRFRF
   481  SNMLKAHKEK CFRVTSPVNV PPAVQIPLTT SPATPVPSVV NTATTPTPPI NMNPVSTLPP
   541  RPIPHPFSHL HIHPHPHHPH HLPIPPVPHL PPPPALFKSE PLNHRGQSED NFLRHLAEKN
   601  SSAQHH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF652 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 9.7 nTPM
breast: 9 nTPM
skin: 6.2 nTPM
spleen: 4.3 nTPM
salivary gland: 4.2 nTPM
retina: 4.1 nTPM

Single-cell type

lacrimal acinar cells: 281 nCPM
salivary acinar cells: 280 nCPM
microglia: 271 nCPM
neutrophils: 236 nCPM
thymocytes: 225 nCPM
oligodendrocytes: 213 nCPM

Immune cell

basophil: 7.7 nTPM
neutrophil: 5.9 nTPM
MAIT T-cell: 3.5 nTPM
non-classical monocyte: 3.5 nTPM
eosinophil: 3.2 nTPM
classical monocyte: 3 nTPM

Brain region

white matter: 51 nTPM
medulla oblongata: 39 nTPM
basal ganglia: 38 nTPM
pons: 36 nTPM
midbrain: 32 nTPM
thalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.82
gnomAD missense Z: 2.35
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF652 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF652 as an antibody target. Whether an autoantibody or antibody against ZNF652 could matter depends on whether native ZNF652 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF652 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF652 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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