Ser/Thr protein kinase, TGFB receptor

Definition

Transforming growth factor-beta (TGF-beta) forms a family with other growth factors. The receptors for most of the members of this growth factor family are related. These proteins are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [[cite:PMID:9023056], [cite:PMID:8047140], [cite:PMID:8909794]]. The C-terminal part of the extracellular domain is conserved. Some of the receptors of this family contain subclass-specific N-terminal extensions of this homology domain. The type I receptors also possess 7 extracellular residues preceding the cysteine box.

12 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (12 proteins: gene, accession, name)

• ACVR1
• ACVR1B
• ACVR1C
• ACVR2A
• ACVR2B
• ACVRL1
• AMHR2
• BMPR1A
• BMPR1B
• BMPR2
• TGFBR1
• TGFBR2