Activin types I and II receptor domain

Definition

This is a hydrophilic cysteine-rich ligand-binding domain found in both TGF-beta receptor types (type I and II). In both types, this domain posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box [[cite:PMID:9309176], [cite:PMID:8299934], [cite:PMID:8397373]]. The Transforming growth factor-beta superfamily of ligands include: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-mullerian hormone (AMH), activin, nodal and TGF-beta. Signalling begins with the binding of a TGF-beta superfamily ligand to a TGF-beta type II receptors. The type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators PMID:9759503. The receptors for most of the members of this growth factor family are related. They are receptor-type kinases of Ser/Thr type, which have a single transmembrane domain and a specific hydrophilic Cys-rich ligand-binding domain [[cite:PMID:9023056], [cite:PMID:8047140], [cite:PMID:8909794]].

9 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (9 proteins: gene, accession, name)

• ACVR1
• ACVR1B
• ACVR1C
• ACVR2A
• ACVR2B
• BMPR1A
• BMPR1B
• BMPR2
• TGFBR1