Seroatlas · Human Serome Atlas

ERFE

Erythroferrone

Also known as: C1QTNF15, CTRP15, ERFE_HUMAN, FAM132B, FLJ37034

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q4G0M1
Gene: ERFE
Ensembl: ENSG00000178752
Chromosome: 2
Canonical length: 354 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables molecular sequestering activity. Involved in negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

354 residues, UniProt reviewed canonical sequence.

>Q4G0M1|ERFE
     1  MAPARRPAGA RLLLVYAGLL AAAAAGLGSP EPGAPSRSRA RREPPPGNEL PRGPGESRAG
    61  PAARPPEPTA ERAHSVDPRD AWMLFVRQSD KGVNGKKRSR GKAKKLKFGL PGPPGPPGPQ
   121  GPPGPIIPPE ALLKEFQLLL KGAVRQRERA EPEPCTCGPA GPVAASLAPV SATAGEDDDD
   181  VVGDVLALLA APLAPGPRAP RVEAAFLCRL RRDALVERRA LHELGVYYLP DAEGAFRRGP
   241  GLNLTSGQYR APVAGFYALA ATLHVALGEP PRRGPPRPRD HLRLLICIQS RCQRNASLEA
   301  IMGLESSSEL FTISVNGVLY LQMGQWTSVF LDNASGCSLT VRSGSHFSAV LLGV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERFE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 23 nTPM
skeletal muscle: 14 nTPM
testis: 12 nTPM
cerebellum: 9.2 nTPM
kidney: 7 nTPM
cerebral cortex: 4 nTPM

Single-cell type

late primary spermatocytes: 68 nCPM
early spermatids: 52 nCPM
myosatellite cells: 26 nCPM
late spermatids: 10 nCPM
erythrocytes: 7 nCPM
endometrial luminal cells: 4.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 5.8 nTPM
basal ganglia: 4.5 nTPM
cerebral cortex: 4.4 nTPM
hippocampal formation: 3.2 nTPM
amygdala: 2.4 nTPM
thalamus: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ERFE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERFE as an antibody target. Whether an autoantibody or antibody against ERFE could matter depends on whether native ERFE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERFE is annotated as secreted, so native ERFE circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ERFE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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