NME2
Nucleoside diphosphate kinase B
Also known as: NDKB_HUMAN, NDPKB, NM23-H2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P22392
- Gene
- NME2
- Ensembl
- ENSG00000243678
- Chromosome
- 17
- Canonical length
- 152 aa
- Protein class
- Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
- Quaternary structure
- Homohexamer
OverviewNCBI Gene
Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>P22392|NME2
1 MANLERTFIA IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF
61 FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI QVGRNIIHGS
121 DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YELocalizationUniProt · AlphaFold · HPA
Whether an antibody against NME2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 948 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 948 nTPM
- pancreas: 761 nTPM
- esophagus: 733 nTPM
- skeletal muscle: 651 nTPM
- skin: 648 nTPM
- kidney: 640 nTPM
Single-cell type
- other brain neurons: 50 nCPM
- brain excitatory neurons: 40 nCPM
- hepatic stellate cells: 39 nCPM
- oligodendrocytes: 39 nCPM
- microglia: 35 nCPM
- brain inhibitory neurons: 34 nCPM
Immune cell
- plasmacytoid DC: 480 nTPM
- myeloid DC: 441 nTPM
- memory B-cell: 340 nTPM
- intermediate monocyte: 326 nTPM
- total PBMC: 299 nTPM
- non-classical monocyte: 284 nTPM
Brain region
- choroid plexus: 400 nTPM
- hypothalamus: 204 nTPM
- thalamus: 199 nTPM
- white matter: 193 nTPM
- medulla oblongata: 183 nTPM
- spinal cord: 182 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about NME2.
Disease | ImmuneIEDB
Conditions an epitope on NME2 was assayed in.
- brain glioma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.46
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.88
- DepMap mean gene effect
- -0.4
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cell adhesion
- CTP biosynthetic process
- GTP biosynthetic process
- integrin-mediated signaling pathway
- ITP biosynthetic process
- negative regulation of apoptotic process
- nucleoside triphosphate biosynthetic process
- positive regulation of DNA-templated transcription
- positive regulation of DNA-templated transcription initiation
- positive regulation of epithelial cell proliferation
- positive regulation of keratinocyte differentiation
- positive regulation of transcription by RNA polymerase II
- regulation of apoptotic process
- regulation of epidermis development
- regulation of fatty acid biosynthetic process
- UTP biosynthetic process
Molecular functions
- ATP binding
- coenzyme A binding
- DNA binding
- DNA-binding transcription activator activity
- G-quadruplex DNA binding
- GDP binding
- identical protein binding
- kinase activity
- metal ion binding
- nucleoside diphosphate kinase activity
- protein histidine kinase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of NME2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads NME2 as an antibody target. Whether an autoantibody or antibody against NME2 could matter depends on whether native NME2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
NME2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label NME2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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