Seroatlas · Human Serome Atlas

CARD19

Caspase recruitment domain-containing protein 19

Also known as: bA370F5.1, BinCARD, C9orf89, CAR19_HUMAN, MGC11115

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96LW7
Gene: CARD19
Ensembl: ENSG00000165233
Chromosome: 9
Canonical length: 228 aa
Protein class: Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable CARD domain binding activity. Predicted to be involved in negative regulation of canonical NF-kappaB signal transduction. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q96LW7|CARD19
     1  MTDQTYCDRL VQDTPFLTGH GRLSEQQVDR IILQLNRYYP QILTNKEAEK FRNPKASLRV
    61  RLCDLLSHLQ RSGERDCQEF YRALYIHAQP LHSRLPSRHA LRKFHITNHA CLVLARGGHP
   121  SLPLMAWMSS MTTQVCCSPG LASPLASAPP QRPPSGPEGR VWQAQAVQML VSVSHFLPLP
   181  PSLSHGSFHT AWGILYVHSC PSFSNLIPRG SLHVCVDSNL VPTAAWRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CARD19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 22 nTPM
testis: 18 nTPM
kidney: 15 nTPM
colon: 13 nTPM
skeletal muscle: 13 nTPM
adrenal gland: 12 nTPM

Single-cell type

platelets: 1,064 nCPM
megakaryocytes: 315 nCPM
late primary spermatocytes: 173 nCPM
neutrophils: 122 nCPM
breast hormone-responsive cells: 115 nCPM
conjunctival goblet cells: 113 nCPM

Immune cell

neutrophil: 41 nTPM
classical monocyte: 38 nTPM
myeloid DC: 31 nTPM
intermediate monocyte: 30 nTPM
basophil: 28 nTPM
eosinophil: 24 nTPM

Brain region

white matter: 15 nTPM
pons: 13 nTPM
cerebellum: 12 nTPM
medulla oblongata: 11 nTPM
spinal cord: 10 nTPM
thalamus: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

negative regulation of canonical NF-kappaB signal transduction

Molecular functions

CARD domain binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Death-like domain superfamily
BinCARD, CARD domain
Caspase recruitment domain-containing protein 19

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CARD19 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BCL10

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CARD19 as an antibody target. Whether an autoantibody or antibody against CARD19 could matter depends on whether native CARD19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CARD19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CARD19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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