Seroatlas · Human Serome Atlas

ANKRD46

Ankyrin repeat domain-containing protein 46

Also known as: ANR46_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86W74
Gene: ANKRD46
Ensembl: ENSG00000186106
Chromosome: 8
Canonical length: 228 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein containing multiple ankyrin repeats. Ankyrin domains function in protein-protein interactions in a variety of cellular processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q86W74|ANKRD46
     1  MSYVFVNDSS QTNVPLLQAC IDGDFNYSKR LLESGFDPNI RDSRGRTGLH LAAARGNVDI
    61  CQLLHKFGAD LLATDYQGNT ALHLCGHVDT IQFLVSNGLK IDICNHQGAT PLVLAKRRGV
   121  NKDVIRLLES LEEQEVKGFN RGTHSKLETM QTAESESAME SHSLLNPNLQ QGEGVLSSFR
   181  TTWQEFVEDL GFWRVLLLIF VIALLSLGIA YYVSGVLPFV ENQPELVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 58 nTPM
cerebral cortex: 40 nTPM
liver: 39 nTPM
adrenal gland: 37 nTPM
tongue: 34 nTPM
retina: 33 nTPM

Single-cell type

adrenal medulla cells: 85 nCPM
adrenal cortex cells: 82 nCPM
myonuclei: 80 nCPM
retinal horizontal cells: 54 nCPM
corticotrophs: 50 nCPM
brain inhibitory neurons: 49 nCPM

Immune cell

naive CD4 T-cell: 18 nTPM
MAIT T-cell: 17 nTPM
NK-cell: 17 nTPM
basophil: 16 nTPM
naive CD8 T-cell: 15 nTPM
gdT-cell: 14 nTPM

Brain region

cerebral cortex: 75 nTPM
basal ganglia: 68 nTPM
white matter: 65 nTPM
hypothalamus: 61 nTPM
spinal cord: 59 nTPM
pons: 59 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.52
gnomAD missense Z: 1.91
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD46 as an antibody target. Whether an autoantibody or antibody against ANKRD46 could matter depends on whether native ANKRD46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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