Seroatlas · Human Serome Atlas

ATP6V1D

V-type proton ATPase subunit D

Also known as: ATP6M, VATD, VATD_HUMAN, VMA8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5K8
Gene: ATP6V1D
Ensembl: ENSG00000100554
Chromosome: 14
Canonical length: 247 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"""""""""""""""""""""""""""""""", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

247 residues, UniProt reviewed canonical sequence.

>Q9Y5K8|ATP6V1D
     1  MSGKDRIEIF PSRMAQTIMK ARLKGAQTGR NLLKKKSDAL TLRFRQILKK IIETKMLMGE
    61  VMREAAFSLA EAKFTAGDFS TTVIQNVNKA QVKIRAKKDN VAGVTLPVFE HYHEGTDSYE
   121  LTGLARGGEQ LAKLKRNYAK AVELLVELAS LQTSFVTLDE AIKITNRRVN AIEHVIIPRI
   181  ERTLAYIITE LDEREREEFY RLKKIQEKKK ILKEKSEKDL EQRRAAGEVL EPANLLAEEK
   241  DEDLLFE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V1D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 128 nTPM
cerebral cortex: 127 nTPM
kidney: 121 nTPM
choroid plexus: 121 nTPM
hypothalamus: 107 nTPM
tongue: 101 nTPM

Single-cell type

esophageal apical cells: 1,788 nCPM
esophageal suprabasal cells: 401 nCPM
neutrophils: 398 nCPM
oocytes: 382 nCPM
syncytiotrophoblasts: 340 nCPM
parietal cells: 263 nCPM

Immune cell

basophil: 107 nTPM
neutrophil: 94 nTPM
eosinophil: 93 nTPM
non-classical monocyte: 84 nTPM
myeloid DC: 84 nTPM
T-reg: 79 nTPM

Brain region

pons: 117 nTPM
cerebral cortex: 114 nTPM
hypothalamus: 109 nTPM
basal ganglia: 105 nTPM
choroid plexus: 105 nTPM
midbrain: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.93
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

rotational mechanism
proton-transporting ATPase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

ATPase, V1 complex, subunit D
ATP synthase subunit D

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP6V1D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6V1D as an antibody target. Whether an autoantibody or antibody against ATP6V1D could matter depends on whether native ATP6V1D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6V1D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6V1D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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