ATP6V1G1

Protein identityUniProt · HPA

UniProt accession

O75348

Gene

ATP6V1G1

Ensembl

ENSG00000136888

Chromosome

9

Canonical length

118 aa

Protein class

Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of three V1 domain G subunit proteins. Pseudogenes of this gene have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

118 residues, UniProt reviewed canonical sequence.

>O75348|ATP6V1G1
     1  MASQSQGIQQ LLQAEKRAAE KVSEARKRKN RRLKQAKEEA QAEIEQYRLQ REKEFKAKEA
    61  AALGSRGSCS TEVEKETQEK MTILQTYFRQ NRDEVLDNLL AFVCDIRPEI HENYRING

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V1G1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

167 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.25

gnomAD pLI

0.1

gnomAD missense Z

0.62

DepMap mean gene effect

-0.94

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to increased oxygen levels
• intracellular iron ion homeostasis
• regulation of macroautophagy
• synaptic vesicle lumen acidification

Molecular functions

• ATP hydrolysis activity
• ATPase binding
• proton-transporting ATPase activity, rotational mechanism

Cellular components

• apical plasma membrane
• cytosol
• extracellular exosome
• extrinsic component of synaptic vesicle membrane
• lysosomal membrane
• plasma membrane
• synaptic vesicle membrane
• vacuolar proton-transporting V-type ATPase, V1 domain

Protein domainsUniProt · Pfam · InterPro

• Vacuolar (H+)-ATPase G subunit
• Vacuolar (H+)-ATPase G subunit

KeywordsUniProt

• Acetylation
• Cell membrane
• Hydrogen ion transport
• Ion transport
• Membrane
• Transport

InteractionsUniProt · HPA

Protein binding partners of ATP6V1G1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATP6V1A
• ATP6V1B1
• ATP6V1B2
• ATP6V1C1
• ATP6V1C2
• ATP6V1D
• ATP6V1E1
• ATP6V1E2
• ATP6V1F
• DMXL1
• DMXL2
• WDR7