Seroatlas · Human Serome Atlas

SNX10

Sorting nexin-10

Also known as: SNX10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y5X0
Gene: SNX10
Ensembl: ENSG00000086300
Chromosome: 7
Canonical length: 201 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Microtubules,Primary cilium,Cytosol

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9Y5X0|SNX10
     1  MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV RRRYREFVWL
    61  RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED FLRKVLQNAL LLSDSSLHLF
   121  LQSHLNSEDI EACVSGQTKY SVEEAIHKFA LMNRRFPEED EEGKKENDID YDSESSSSGL
   181  GHSSDDSSSH GCKVNTAPQE S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 43 nTPM
liver: 41 nTPM
retina: 32 nTPM
lung: 28 nTPM
spleen: 27 nTPM
appendix: 26 nTPM

Single-cell type

neutrophils: 1,029 nCPM
kupffer cells: 413 nCPM
distal convoluted tubule cells: 363 nCPM
neutrophil progenitors: 286 nCPM
müller glia: 267 nCPM
monocytes: 253 nCPM

Immune cell

neutrophil: 181 nTPM
non-classical monocyte: 91 nTPM
intermediate monocyte: 89 nTPM
classical monocyte: 76 nTPM
myeloid DC: 54 nTPM
memory B-cell: 44 nTPM

Brain region

hypothalamus: 71 nTPM
pons: 63 nTPM
thalamus: 47 nTPM
cerebral cortex: 44 nTPM
medulla oblongata: 43 nTPM
midbrain: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNX10.

Disease | AllUniProt

Conditions SNX10 is implicated in, by any mechanism.

Osteopetrosis, autosomal recessive 8 (OPTB8) MIM:615085

Disease | GeneticClinVar

21 pathogenic / likely-pathogenic of 164 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Autosomal recessive osteopetrosis 8
Gastric cancer
Osteopetrosis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 0.55
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

apical cytoplasm
centrosome
endoplasmic reticulum
endosome
nucleus
secretory granule
extrinsic component of endosome membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ATP6V1D

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX10 as an antibody target. Whether an autoantibody or antibody against SNX10 could matter depends on whether native SNX10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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