Seroatlas · Human Serome Atlas

ATP6V1F

V-type proton ATPase subunit F

Also known as: ATP6S14, VATF, VATF_HUMAN, Vma7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16864
Gene: ATP6V1F
Ensembl: ENSG00000128524
Chromosome: 7
Canonical length: 119 aa
Protein class: Metabolic proteins, Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"""""""""""""""""""""""""""""""", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>Q16864|ATP6V1F
     1  MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED TFRQFLNRDD
    61  IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA AKDSILRRAR GMFTAEDLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V1F can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 343 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 343 nTPM
amygdala: 312 nTPM
kidney: 310 nTPM
basal ganglia: 289 nTPM
hippocampal formation: 280 nTPM
hypothalamus: 279 nTPM

Single-cell type

late spermatids: 1,415 nCPM
hofbauer cells: 1,269 nCPM
esophageal apical cells: 1,063 nCPM
esophageal suprabasal cells: 1,030 nCPM
late primary spermatocytes: 933 nCPM
epididymal clear cells: 586 nCPM

Immune cell

total PBMC: 887 nTPM
classical monocyte: 699 nTPM
myeloid DC: 510 nTPM
eosinophil: 491 nTPM
intermediate monocyte: 476 nTPM
basophil: 371 nTPM

Brain region

hypothalamus: 212 nTPM
cerebral cortex: 196 nTPM
basal ganglia: 185 nTPM
pons: 184 nTPM
thalamus: 178 nTPM
hippocampal formation: 176 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0.01
gnomAD missense Z: 0.66
DepMap mean gene effect: -1.12
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

ATPase, V1 complex, subunit F, eukaryotic
ATPase, V1 complex, subunit F
ATPase, V1 complex, subunit F superfamily
ATP synthase (F/14-kDa) subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP6V1F in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6V1F as an antibody target. Whether an autoantibody or antibody against ATP6V1F could matter depends on whether native ATP6V1F is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6V1F is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6V1F as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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