BBLN
Bublin coiled-coil protein
Also known as: BBLN_HUMAN, C9orf16, EST00098, FLJ12823, MGC4639
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BUW7
- Gene
- BBLN
- Ensembl
- ENSG00000171159
- Chromosome
- 9
- Canonical length
- 83 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Microtubules
OverviewNCBI Gene
Enables molecular adaptor activity. Involved in intermediate filament bundle assembly. Located in cell junction; polymeric cytoskeletal fiber; and subapical part of cell. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
83 residues, UniProt reviewed canonical sequence.
>Q9BUW7|BBLN
1 MSGPNGDLGM PVEAGAEGEE DGFGEAEYAA INSMLDQINS CLDHLEEKND HLHARLQELL
61 ESNRQTRLEF QQQLGEAPSD ASPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BBLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 619 nTPM
Expression across tissuesHPA
Tissue
- hippocampal formation: 619 nTPM
- amygdala: 429 nTPM
- adrenal gland: 335 nTPM
- cerebral cortex: 306 nTPM
- basal ganglia: 188 nTPM
- midbrain: 167 nTPM
Single-cell type
- late spermatids: 1,589 nCPM
- esophageal apical cells: 948 nCPM
- platelets: 825 nCPM
- urothelial cells: 659 nCPM
- prostatic hillock cells: 609 nCPM
- megakaryocytes: 575 nCPM
Immune cell
- T-reg: 256 nTPM
- basophil: 223 nTPM
- eosinophil: 206 nTPM
- memory CD4 T-cell: 179 nTPM
- naive B-cell: 179 nTPM
- MAIT T-cell: 170 nTPM
Brain region
- hippocampal formation: 521 nTPM
- cerebral cortex: 435 nTPM
- amygdala: 226 nTPM
- white matter: 178 nTPM
- thalamus: 172 nTPM
- pons: 148 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0.02
- DepMap mean gene effect
- -0.17
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic signaling pathway
- bone development
- bone resorption
- gene expression
- intermediate filament bundle assembly
- multinuclear osteoclast differentiation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Bublin coiled-coil protein-like, eukaryota
- Uncharacterised protein family (UPF0184)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BBLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BBLN as an antibody target. Whether an autoantibody or antibody against BBLN could matter depends on whether native BBLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BBLN is annotated at the cell surface, where native BBLN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label BBLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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