Seroatlas · Human Serome Atlas

TOMM34

Mitochondrial import receptor subunit TOM34

Also known as: HTOM34P, TOM34, TOM34_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15785
Gene
TOMM34
Ensembl
ENSG00000025772
Chromosome
20
Canonical length
309 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Mitochondria,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q15785|TOMM34
     1  MAPKFPDSVE ELRAAGNESF RNGQYAEASA LYGRALRVLQ AQGSSDPEEE SVLYSNRAAC
    61  HLKDGNCRDC IKDCTSALAL VPFSIKPLLR RASAYEALEK YPMAYVDYKT VLQIDDNVTS
   121  AVEGINRMTR ALMDSLGPEW RLKLPSIPLV PVSAQKRWNS LPSENHKEMA KSKSKETTAT
   181  KNRVPSAGDV EKARVLKEEG NELVKKGNHK KAIEKYSESL LCSNLESATY SNRALCYLVL
   241  KQYTEAVKDC TEALKLDGKN VKAFYRRAQA HKALKDYKSS FADISNLLQI EPRNGPAQKL
   301  RQEVKQNLH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TOMM34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
119 nTPM

Expression across tissuesHPA

Tissue

  • testis: 119 nTPM
  • basal ganglia: 88 nTPM
  • hippocampal formation: 66 nTPM
  • adrenal gland: 46 nTPM
  • epididymis: 46 nTPM
  • fallopian tube: 46 nTPM

Single-cell type

  • oocytes: 207 nCPM
  • cytotrophoblasts: 163 nCPM
  • migrating cytotrophoblasts: 95 nCPM
  • undifferentiated spermatogonia: 82 nCPM
  • urothelial cells: 78 nCPM
  • late primary spermatocytes: 71 nCPM

Immune cell

  • myeloid DC: 40 nTPM
  • naive B-cell: 29 nTPM
  • memory B-cell: 26 nTPM
  • plasmacytoid DC: 21 nTPM
  • T-reg: 19 nTPM
  • non-classical monocyte: 19 nTPM

Brain region

  • hippocampal formation: 82 nTPM
  • cerebral cortex: 75 nTPM
  • basal ganglia: 52 nTPM
  • white matter: 41 nTPM
  • hypothalamus: 38 nTPM
  • amygdala: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TOMM34.

Disease | ImmuneIEDB

Conditions an epitope on TOMM34 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0.01
gnomAD missense Z
1.22
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TOMM34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TOMM34 as an antibody target. Whether an autoantibody or antibody against TOMM34 could matter depends on whether native TOMM34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TOMM34 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TOMM34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TOMM34. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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