Seroatlas · Human Serome Atlas

ATP6V1E2

V-type proton ATPase subunit E 2

Also known as: ATP6E1, ATP6EL2, ATP6V1EL2, MGC9341, VATE2_HUMAN, VMA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A05
Gene: ATP6V1E2
Ensembl: ENSG00000250565
Chromosome: 2
Canonical length: 226 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in regulation of macroautophagy. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in cytosol. Predicted to be part of proton-transporting two-sector ATPase complex, catalytic domain. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q96A05|ATP6V1E2
     1  MALSDVDVKK QIKHMMAFIE QEANEKAEEI DAKAEEEFNI EKGRLVQTQR LKIMEYYEKK
    61  EKQIEQQKKI LMSTMRNQAR LKVLRARNDL ISDLLSEAKL RLSRIVEDPE VYQGLLDKLV
   121  LQGLLRLLEP VMIVRCRPQD LLLVEAAVQK AIPEYMTISQ KHVEVQIDKE AYLAVNAAGG
   181  VEVYSGNQRI KVSNTLESRL DLSAKQKMPE IRMALFGANT NRKFFI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP6V1E2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

testis: 27 nTPM
epididymis: 6.1 nTPM
basal ganglia: 4.1 nTPM
spinal cord: 3.9 nTPM
amygdala: 3.6 nTPM
midbrain: 3.6 nTPM

Single-cell type

early spermatids: 449 nCPM
late spermatids: 344 nCPM
late primary spermatocytes: 325 nCPM
epididymal principal cells: 88 nCPM
epididymal basal cells: 47 nCPM
megakaryocytes: 43 nCPM

Immune cell

naive CD8 T-cell: 1.7 nTPM
plasmacytoid DC: 1.7 nTPM
memory CD8 T-cell: 1.6 nTPM
memory CD4 T-cell: 1.5 nTPM
MAIT T-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

basal ganglia: 4.7 nTPM
amygdala: 4.4 nTPM
white matter: 4.3 nTPM
medulla oblongata: 4.2 nTPM
spinal cord: 4.2 nTPM
pons: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.55
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of macroautophagy

Molecular functions

rotational mechanism
proton-transporting ATPase activity

Cellular components

acrosomal vesicle
cytosol
proton-transporting two-sector ATPase complex, catalytic domain

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP6V1E2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP6V1E2 as an antibody target. Whether an autoantibody or antibody against ATP6V1E2 could matter depends on whether native ATP6V1E2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP6V1E2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATP6V1E2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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