Seroatlas · Human Serome Atlas

SLC38A1

Sodium-coupled neutral amino acid symporter 1

Also known as: ATA1, NAT2, S38A1_HUMAN, SAT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H2H9
Gene
SLC38A1
Ensembl
ENSG00000111371
Chromosome
12
Canonical length
487 aa
Protein class
FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q9H2H9|SLC38A1
     1  MMHFKSGLEL TELQNMTVPE DDNISNDSND FTEVENGQIN SKFISDRESR RSLTNSHLEK
    61  KKCDEYIPGT TSLGMSVFNL SNAIMGSGIL GLAFALANTG ILLFLVLLTS VTLLSIYSIN
   121  LLLICSKETG CMVYEKLGEQ VFGTTGKFVI FGATSLQNTG AMLSYLFIVK NELPSAIKFL
   181  MGKEETFSAW YVDGRVLVVI VTFGIILPLC LLKNLGYLGY TSGFSLSCMV FFLIVVIYKK
   241  FQIPCIVPEL NSTISANSTN ADTCTPKYVT FNSKTVYALP TIAFAFVCHP SVLPIYSELK
   301  DRSQKKMQMV SNISFFAMFV MYFLTAIFGY LTFYDNVQSD LLHKYQSKDD ILILTVRLAV
   361  IVAVILTVPV LFFTVRSSLF ELAKKTKFNL CRHTVVTCIL LVVINLLVIF IPSMKDIFGV
   421  VGVTSANMLI FILPSSLYLK ITDQDGDKGT QRIWAALFLG LGVLFSLVSI PLVIYDWACS
   481  SSSDEGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC38A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
84 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 84 nTPM
  • breast: 77 nTPM
  • tongue: 77 nTPM
  • parathyroid gland: 74 nTPM
  • retina: 73 nTPM
  • lymph node: 60 nTPM

Single-cell type

  • bergmann glia: 861 nCPM
  • nk-cells: 605 nCPM
  • retinal bipolar cells: 573 nCPM
  • renal collecting duct principal cells: 551 nCPM
  • t-cells: 547 nCPM
  • endometrial luminal cells: 468 nCPM

Immune cell

  • MAIT T-cell: 71 nTPM
  • NK-cell: 68 nTPM
  • T-reg: 64 nTPM
  • naive CD4 T-cell: 63 nTPM
  • memory CD8 T-cell: 61 nTPM
  • naive B-cell: 58 nTPM

Brain region

  • white matter: 167 nTPM
  • spinal cord: 147 nTPM
  • cerebellum: 143 nTPM
  • medulla oblongata: 138 nTPM
  • hypothalamus: 135 nTPM
  • pons: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.93
gnomAD missense Z
2.15
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC38A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC38A1 as an antibody target. Whether an autoantibody or antibody against SLC38A1 could matter depends on whether native SLC38A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC38A1 is annotated at the cell surface, where native SLC38A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC38A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC38A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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