Seroatlas · Human Serome Atlas

ELMOD2

ELMO domain-containing protein 2

Also known as: ELMD2_HUMAN, MGC10084

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZ81
Gene: ELMOD2
Ensembl: ENSG00000179387
Chromosome: 4
Canonical length: 293 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Actin filaments,Cytosol

OverviewNCBI Gene

This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q8IZ81|ELMOD2
     1  MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ
    61  KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL QITGYKQLYL DVESVRKRPY
   121  DSDNLQHEEL LMKLWNLLMP TKKLNARISK QWAEIGFQGD DPKTDFRGMG ILGLINLVYF
   181  SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH
   241  FHQFYCYLVY EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELMOD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

retina: 17 nTPM
thyroid gland: 16 nTPM
liver: 15 nTPM
parathyroid gland: 15 nTPM
small intestine: 14 nTPM
kidney: 14 nTPM

Single-cell type

adrenal medulla cells: 64 nCPM
prostatic glandular cells: 58 nCPM
ependymal cells: 57 nCPM
cardiomyocytes: 55 nCPM
gonadotrophs: 54 nCPM
corticotrophs: 52 nCPM

Immune cell

neutrophil: 15 nTPM
plasmacytoid DC: 9.8 nTPM
eosinophil: 8.1 nTPM
NK-cell: 7.6 nTPM
MAIT T-cell: 7.4 nTPM
T-reg: 7.3 nTPM

Brain region

choroid plexus: 27 nTPM
white matter: 23 nTPM
cerebellum: 21 nTPM
spinal cord: 19 nTPM
medulla oblongata: 19 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.42
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELMOD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ARL2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELMOD2 as an antibody target. Whether an autoantibody or antibody against ELMOD2 could matter depends on whether native ELMOD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELMOD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELMOD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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