Seroatlas · Human Serome Atlas

P2RX4

P2X purinoceptor 4

Also known as: P2RX4_HUMAN, P2X4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99571
Gene
P2RX4
Ensembl
ENSG00000135124
Chromosome
12
Canonical length
388 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q99571|P2RX4
     1  MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW EKGYQETDSV
    61  VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF VMTNVILTMN QTQGLCPEIP
   121  DATTVCKSDA SCTAGSAGTH SNGVSTGRCV AFNGSVKTCE VAAWCPVEDD THVPQPAFLK
   181  AAENFTLLVK NNIWYPKFNF SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG
   241  HSFQDMAVEG GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY
   301  RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT VLCDIIVLYC
   361  MKKRLYYREK KYKYVEDYEQ GLASELDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against P2RX4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 36 nTPM
  • colon: 31 nTPM
  • parathyroid gland: 31 nTPM
  • small intestine: 31 nTPM
  • placenta: 31 nTPM
  • rectum: 28 nTPM

Single-cell type

  • syncytiotrophoblasts: 205 nCPM
  • migrating cytotrophoblasts: 201 nCPM
  • cytotrophoblasts: 177 nCPM
  • hofbauer cells: 172 nCPM
  • goblet cells: 157 nCPM
  • monocytes: 149 nCPM

Immune cell

  • basophil: 73 nTPM
  • intermediate monocyte: 63 nTPM
  • classical monocyte: 59 nTPM
  • non-classical monocyte: 55 nTPM
  • total PBMC: 33 nTPM
  • myeloid DC: 33 nTPM

Brain region

  • cerebellum: 11 nTPM
  • white matter: 9.7 nTPM
  • medulla oblongata: 7.4 nTPM
  • thalamus: 7.3 nTPM
  • spinal cord: 6.9 nTPM
  • pons: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.28
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of P2RX4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads P2RX4 as an antibody target. Whether an autoantibody or antibody against P2RX4 could matter depends on whether native P2RX4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

P2RX4 is annotated at the cell surface, where native P2RX4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label P2RX4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/P2RX4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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