GABPB2
GA-binding protein subunit beta-2
Also known as: GABP2_HUMAN, MGC29891
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8TAK5
- Gene
- GABPB2
- Ensembl
- ENSG00000143458
- Chromosome
- 1
- Canonical length
- 448 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
Enables transcription cis-regulatory region binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
448 residues, UniProt reviewed canonical sequence.
>Q8TAK5|GABPB2
1 MSLVDLGKRL LEAARKGQDD EVRTLMANGA PFTTDWLGTS PLHLAAQYGH YSTAEVLLRA
61 GVSRDARTKV DRTPLHMAAA DGHAHIVELL VRNGADVNAK DMLKMTALHW ATERHHRDVV
121 ELLIKYGADV HAFSKFDKSA FDIALEKNNA EILVILQEAM QNQVNVNPER ANPVTDPVSM
181 AAPFIFTSGE VVNLASLISS TNTKTTSGDP HASTVQFSNS TTSVLATLAA LAEASVPLSN
241 SHRATANTEE IIEGNSVDSS IQQVMGSGGQ RVITIVTDGV PLGNIQTSIP TGGIGQPFIV
301 TVQDGQQVLT VPAGKVAEET VIKEEEEEKL PLTKKPRIGE KTNSVEESKE GNERELLQQQ
361 LQEANRRAQE YRHQLLKKEQ EAEQYRLKLE AIARQQPNGV DFTMVEEVAE VDAVVVTEGE
421 LEERETKVTG SAGTTEPHTR VSMATVSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against GABPB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 11 nTPM
Expression across tissuesHPA
Tissue
- testis: 11 nTPM
- thymus: 9.1 nTPM
- ovary: 8.9 nTPM
- blood vessel: 7.3 nTPM
- skin: 6.7 nTPM
- bone marrow: 6.5 nTPM
Single-cell type
- myonuclei: 232 nCPM
- choroid plexus epithelial cells: 131 nCPM
- early primary spermatocytes: 118 nCPM
- adipocytes: 104 nCPM
- distal convoluted tubule cells: 91 nCPM
- podocytes: 91 nCPM
Immune cell
- non-classical monocyte: 1.8 nTPM
- plasmacytoid DC: 1.6 nTPM
- memory CD4 T-cell: 1.5 nTPM
- neutrophil: 1.5 nTPM
- basophil: 1.4 nTPM
- naive CD8 T-cell: 1.4 nTPM
Brain region
- white matter: 20 nTPM
- cerebellum: 19 nTPM
- basal ganglia: 18 nTPM
- cerebral cortex: 17 nTPM
- thalamus: 16 nTPM
- medulla oblongata: 16 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.88
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.85
- DepMap mean gene effect
- -0.22
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of GABPB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads GABPB2 as an antibody target. Whether an autoantibody or antibody against GABPB2 could matter depends on whether native GABPB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
GABPB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label GABPB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...