Seroatlas · Human Serome Atlas

THAP5

THAP domain-containing protein 5

Also known as: DKFZp313O1132, THAP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6K1
Gene: THAP5
Ensembl: ENSG00000177683
Chromosome: 7
Canonical length: 395 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables protease binding activity. Involved in negative regulation of cell cycle and negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>Q7Z6K1|THAP5
     1  MPRYCAAICC KNRRGRNNKD RKLSFYPFPL HDKERLEKWL KNMKRDSWVP SKYQFLCSDH
    61  FTPDSLDIRW GIRYLKQTAV PTIFSLPEDN QGKDPSKKKS QKKNLEDEKE VCPKAKSEES
   121  FVLNETKKNI VNTDVPHQHP ELLHSSSLVK PPAPKTGSIQ NNMLTLNLVK QHTGKPESTL
   181  ETSVNQDTGR GGFHTCFENL NSTTITLTTS NSESIHQSLE TQEVLEVTTS HLANPNFTSN
   241  SMEIKSAQEN PFLFSTINQT VEELNTNKES VIAIFVPAEN SKPSVNSFIS AQKETTEMED
   301  TDIEDSLYKD VDYGTEVLQI EHSYCRQDIN KEHLWQKVSK LHSKITLLEL KEQQTLGRLK
   361  SLEALIRQLK QENWLSEENV KIIENHFTTY EVTMI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against THAP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

testis: 25 nTPM
thyroid gland: 21 nTPM
liver: 18 nTPM
parathyroid gland: 17 nTPM
retina: 16 nTPM
ovary: 15 nTPM

Single-cell type

late spermatids: 115 nCPM
early spermatids: 62 nCPM
late primary spermatocytes: 21 nCPM
cholangiocytes: 14 nCPM
epididymal principal cells: 14 nCPM
corticotrophs: 12 nCPM

Immune cell

neutrophil: 26 nTPM
naive B-cell: 20 nTPM
basophil: 19 nTPM
memory B-cell: 18 nTPM
naive CD4 T-cell: 17 nTPM
non-classical monocyte: 16 nTPM

Brain region

white matter: 34 nTPM
cerebellum: 31 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 27 nTPM
hypothalamus: 27 nTPM
spinal cord: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.13
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of THAP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads THAP5 as an antibody target. Whether an autoantibody or antibody against THAP5 could matter depends on whether native THAP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

THAP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label THAP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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