Seroatlas · Human Serome Atlas

BABAM1

BRISC and BRCA1-A complex member 1

Also known as: BABA1_HUMAN, C19orf62, FLJ20571, HSPC142, MERIT40, NBA1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NWV8
Gene
BABAM1
Ensembl
ENSG00000105393
Chromosome
19
Canonical length
329 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Located in cytosol and nuclear body. Part of BRCA1-A complex and BRISC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>Q9NWV8|BABAM1
     1  MEVAEPSSPT EEEEEEEEHS AEPRPRTRSN PEGAEDRAVG AQASVGSRSE GEGEAASADD
    61  GSLNTSGAGP KSWQVPPPAP EVQIRTPRVN CPEKVIICLD LSEEMSLPKL ESFNGSKTNA
   121  LNVSQKMIEM FVRTKHKIDK SHEFALVVVN DDTAWLSGLT SDPRELCSCL YDLETASCST
   181  FNLEGLFSLI QQKTELPVTE NVQTIPPPYV VRTILVYSRP PCQPQFSLTE PMKKMFQCPY
   241  FFFDVVYIHN GTEEKEEEMS WKDMFAFMGS LDTKGTSYKY EVALAGPALE LHNCMAKLLA
   301  HPLQRPCQSH ASYSLLEEED EAIEVEATV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BABAM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
126 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 126 nTPM
  • cerebral cortex: 95 nTPM
  • tongue: 90 nTPM
  • amygdala: 80 nTPM
  • heart muscle: 72 nTPM
  • hippocampal formation: 70 nTPM

Single-cell type

  • other brain neurons: 28 nCPM
  • brain excitatory neurons: 28 nCPM
  • brain inhibitory neurons: 24 nCPM
  • oligodendrocytes: 22 nCPM
  • microglia: 20 nCPM
  • oligodendrocyte progenitor cells: 20 nCPM

Immune cell

  • total PBMC: 214 nTPM
  • basophil: 202 nTPM
  • T-reg: 181 nTPM
  • eosinophil: 168 nTPM
  • myeloid DC: 161 nTPM
  • classical monocyte: 155 nTPM

Brain region

  • cerebral cortex: 72 nTPM
  • pons: 65 nTPM
  • basal ganglia: 65 nTPM
  • hypothalamus: 64 nTPM
  • white matter: 63 nTPM
  • midbrain: 60 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.96
gnomAD missense Z
1.17
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BABAM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BABAM1 as an antibody target. Whether an autoantibody or antibody against BABAM1 could matter depends on whether native BABAM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BABAM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BABAM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BABAM1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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