Seroatlas · Human Serome Atlas

BABAM2

BRISC and BRCA1-A complex member 2

Also known as: BABA2_HUMAN, BRCC4, BRCC45, BRE

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NXR7
Gene
BABAM2
Ensembl
ENSG00000158019
Chromosome
2
Canonical length
383 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q9NXR7|BABAM2
     1  MSPEVALNRI SPMLSPFISS VVRNGKVGLD ATNCLRITDL KSGCTSLTPG PNCDRFKLHI
    61  PYAGETLKWD IIFNAQYPEL PPDFIFGEDA EFLPDPSALQ NLASWNPSNP ECLLLVVKEL
   121  VQQYHQFQCS RLRESSRLMF EYQTLLEEPQ YGENMEIYAG KKNNWTGEFS ARFLLKLPVD
   181  FSNIPTYLLK DVNEDPGEDV ALLSVSFEDT EATQVYPKLY LSPRIEHALG GSSALHIPAF
   241  PGGGCLIDYV PQVCHLLTNK VQYVIQGYHK RREYIAAFLS HFGTGVVEYD AEGFTKLTLL
   301  LMWKDFCFLV HIDLPLFFPR DQPTLTFQSV YHFTNSGQLY SQAQKNYPYS PRWDGNEMAK
   361  RAKAYFKTFV PQFQEAAFAN GKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BABAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
357 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 357 nTPM
  • skeletal muscle: 70 nTPM
  • tongue: 51 nTPM
  • heart muscle: 51 nTPM
  • kidney: 50 nTPM
  • blood vessel: 44 nTPM

Single-cell type

  • adrenal cortex cells: 2,215 nCPM
  • renal connecting tubule cells: 714 nCPM
  • neutrophils: 578 nCPM
  • distal convoluted tubule cells: 505 nCPM
  • myonuclei: 441 nCPM
  • thymic myoid cells: 434 nCPM

Immune cell

  • basophil: 107 nTPM
  • myeloid DC: 86 nTPM
  • classical monocyte: 66 nTPM
  • MAIT T-cell: 65 nTPM
  • T-reg: 62 nTPM
  • NK-cell: 59 nTPM

Brain region

  • pons: 61 nTPM
  • hypothalamus: 55 nTPM
  • cerebral cortex: 51 nTPM
  • choroid plexus: 47 nTPM
  • basal ganglia: 47 nTPM
  • hippocampal formation: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.17
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • BRCA1-A complex subunit BRE
  • Brain and reproductive organ-expressed protein (BRE)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BABAM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BABAM2 as an antibody target. Whether an autoantibody or antibody against BABAM2 could matter depends on whether native BABAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BABAM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BABAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BABAM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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