Seroatlas · Human Serome Atlas

LDOC1

Protein LDOC1

Also known as: BCUR1, LDOC1_HUMAN, Mar7, Mart7, RTL7, SIRH7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95751
Gene: LDOC1
Ensembl: ENSG00000182195
Chromosome: X
Canonical length: 146 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>O95751|LDOC1
     1  MVDELVLLLH ALLMRHRALS IENSQLMEQL RLLVCERASL LRQVRPPSCP VPFPETFNGE
    61  SSRLPEFIVQ TASYMLVNEN RFCNDAMKVA FLISLLTGEA EEWVVPYIEM DSPILGDYRA
   121  FLDEMKQCFG WDDDEDDDDE EEEDDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LDOC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 55 nTPM
pituitary gland: 22 nTPM
cerebral cortex: 17 nTPM
basal ganglia: 14 nTPM
hippocampal formation: 14 nTPM
hypothalamus: 13 nTPM

Single-cell type

vascular smooth muscle cells: 61 nCPM
oocytes: 60 nCPM
decidual stromal cells: 54 nCPM
fallopian secretory cells: 42 nCPM
breast secretory cells: 41 nCPM
salivary acinar cells: 39 nCPM

Immune cell

NK-cell: 6.4 nTPM
basophil: 3.1 nTPM
T-reg: 2.6 nTPM
memory CD4 T-cell: 2.5 nTPM
naive CD4 T-cell: 2.2 nTPM
naive B-cell: 2.1 nTPM

Brain region

cerebral cortex: 28 nTPM
hippocampal formation: 28 nTPM
white matter: 27 nTPM
hypothalamus: 26 nTPM
basal ganglia: 26 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.52
gnomAD missense Z: 1.56
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of LDOC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LDOC1 as an antibody target. Whether an autoantibody or antibody against LDOC1 could matter depends on whether native LDOC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LDOC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LDOC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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