Seroatlas · Human Serome Atlas

ABRA

Actin-binding Rho-activating protein

Also known as: ABRA_HUMAN, STARS

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N0Z2
Gene: ABRA
Ensembl: ENSG00000174429
Chromosome: 8
Canonical length: 381 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization; positive regulation of Rho protein signal transduction; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of DNA-templated transcription and protein import into nucleus. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

381 residues, UniProt reviewed canonical sequence.

>Q8N0Z2|ABRA
     1  MAPGEKESGE GPAKSALRKI RTATLVISLA RGWQQWANEN SIRQAQEPTG WLPGGTQDSP
    61  QAPKPITPPT SHQKAQSAPK SPPRLPEGHG DGQSSEKAPE VSHIKKKEVS KTVVSKTYER
   121  GGDVSHLSHR YERDAGVLEP GQPENDIDRI LHSHGSPTRR RKCANLVSEL TKGWRVMEQE
   181  EPTWRSDSVD TEDSGYGGEA EERPEQDGVQ VAVVRIKRPL PSQVNRFTEK LNCKAQQKYS
   241  PVGNLKGRWQ QWADEHIQSQ KLNPFSEEFD YELAMSTRLH KGDEGYGRPK EGTKTAERAK
   301  RAEEHIYREM MDMCFIICTM ARHRRDGKIQ VTFGDLFDRY VRISDKVVGI LMRARKHGLV
   361  DFEGEMLWQG RDDHVVITLL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 136 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 136 nTPM
tongue: 60 nTPM
heart muscle: 30 nTPM
esophagus: 2.8 nTPM
blood vessel: 2.1 nTPM
testis: 2 nTPM

Single-cell type

late primary spermatocytes: 158 nCPM
thymic myoid cells: 135 nCPM
myonuclei: 122 nCPM
early spermatids: 79 nCPM
cardiomyocytes: 22 nCPM
epicardial cells: 16 nCPM

Immune cell

eosinophil: 0.2 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 5.9 nTPM
white matter: 2.7 nTPM
cerebral cortex: 2.4 nTPM
pons: 1.6 nTPM
basal ganglia: 1.5 nTPM
medulla oblongata: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: -0.15
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

actin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Costars domain
Costars domain superfamily
Costars
Actin-binding Rho-activating protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABRA as an antibody target. Whether an autoantibody or antibody against ABRA could matter depends on whether native ABRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABRA is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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