FG-GAP repeat

Definition

This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure PMID:8990162. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat PMID:8990162. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding PMID:7929213. A putative Ca2+ binding motif is found in some of the repeats.

19 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (19 proteins: gene, accession, name)

• GPLD1
• ITGA1
• ITGA10
• ITGA11
• ITGA2
• ITGA2B
• ITGA3
• ITGA4
• ITGA5
• ITGA6
• ITGA7
• ITGA8
• ITGA9
• ITGAD
• ITGAE
• ITGAL
• ITGAM
• ITGAV
• ITGAX