Seroatlas · Human Serome Atlas

ITGA3

Integrin alpha-3

Also known as: CD49c, GAP-B3, ITA3_HUMAN, MSK18, VCA-2, VLA3a

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P26006
Gene: ITGA3
Ensembl: ENSG00000005884
Chromosome: 17
Canonical length: 1051 aa
Protein class: Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast cancer metastasis. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

1051 residues, UniProt reviewed canonical sequence.

>P26006|ITGA3
     1  MGPGPSRAPR APRLMLCALA LMVAAGGCVV SAFNLDTRFL VVKEAGNPGS LFGYSVALHR
    61  QTERQQRYLL LAGAPRELAV PDGYTNRTGA VYLCPLTAHK DDCERMNITV KNDPGHHIIE
   121  DMWLGVTVAS QGPAGRVLVC AHRYTQVLWS GSEDQRRMVG KCYVRGNDLE LDSSDDWQTY
   181  HNEMCNSNTD YLETGMCQLG TSGGFTQNTV YFGAPGAYNW KGNSYMIQRK EWDLSEYSYK
   241  DPEDQGNLYI GYTMQVGSFI LHPKNITIVT GAPRHRHMGA VFLLSQEAGG DLRRRQVLEG
   301  SQVGAYFGSA IALADLNNDG WQDLLVGAPY YFERKEEVGG AIYVFMNQAG TSFPAHPSLL
   361  LHGPSGSAFG LSVASIGDIN QDGFQDIAVG APFEGLGKVY IYHSSSKGLL RQPQQVIHGE
   421  KLGLPGLATF GYSLSGQMDV DENFYPDLLV GSLSDHIVLL RARPVINIVH KTLVPRPAVL
   481  DPALCTATSC VQVELCFAYN QSAGNPNYRR NITLAYTLEA DRDRRPPRLR FAGSESAVFH
   541  GFFSMPEMRC QKLELLLMDN LRDKLRPIII SMNYSLPLRM PDRPRLGLRS LDAYPILNQA
   601  QALENHTEVQ FQKECGPDNK CESNLQMRAA FVSEQQQKLS RLQYSRDVRK LLLSINVTNT
   661  RTSERSGEDA HEALLTLVVP PALLLSSVRP PGACQANETI FCELGNPFKR NQRMELLIAF
   721  EVIGVTLHTR DLQVQLQLST SSHQDNLWPM ILTLLVDYTL QTSLSMVNHR LQSFFGGTVM
   781  GESGMKTVED VGSPLKYEFQ VGPMGEGLVG LGTLVLGLEW PYEVSNGKWL LYPTEITVHG
   841  NGSWPCRPPG DLINPLNLTL SDPGDRPSSP QRRRRQLDPG GGQGPPPVTL AAAKKAKSET
   901  VLTCATGRAH CVWLECPIPD APVVTNVTVK ARVWNSTFIE DYRDFDRVRV NGWATLFLRT
   961  SIPTINMENK TTWFSVDIDS ELVEELPAEI ELWLVLVAVG AGLLLLGLII LLLWKCGFFK
  1021  RARTRALYEA KRQKAEMKSQ PSETERLTDD Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ITGA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 84 nTPM
lung: 62 nTPM
kidney: 62 nTPM
urinary bladder: 44 nTPM
thyroid gland: 41 nTPM
skin: 29 nTPM

Single-cell type

alveolar cells type 1: 501 nCPM
podocytes: 417 nCPM
urothelial cells: 243 nCPM
papillary tip epithelial cells: 210 nCPM
transitional alveolar cells: 169 nCPM
ocular epithelial cells: 148 nCPM

Immune cell

gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

pons: 28 nTPM
hypothalamus: 26 nTPM
medulla oblongata: 19 nTPM
midbrain: 17 nTPM
cerebellum: 15 nTPM
cerebral cortex: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ITGA3.

Disease | AllUniProt

Conditions ITGA3 is implicated in, by any mechanism.

Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome (JEB7) MIM:614748

Disease | GeneticClinVar

30 pathogenic / likely-pathogenic of 600 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome
ITGA3-related disorder
Nephrotic syndrome
Malignant tumor of esophagus

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 2.36
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ITGA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ITGA3 as an antibody target. Whether an autoantibody or antibody against ITGA3 could matter depends on whether native ITGA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ITGA3 is annotated at the cell surface, where native ITGA3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ITGA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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