PLAT/LH2 domain

Definition

This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase [pfam:PF01114], which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.

21 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (21 proteins: gene, accession, name)

• ALOX12
• ALOX12B
• ALOX15
• ALOX15B
• ALOX5
• ALOXE3
• DENND5A
• DENND5B
• LIPC
• LIPG
• LOXHD1
• LPL
• PKD1
• PKD1L1
• PKD1L2
• PKD1L3
• PKDREJ
• PNLIP
• PNLIPRP1
• PNLIPRP2
• PNLIPRP3