Seroatlas · Human Serome Atlas

ALOX15

Polyunsaturated fatty acid lipoxygenase ALOX15

Also known as: 15-LOX-1, LOX15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16050
Gene
ALOX15
Ensembl
ENSG00000161905
Chromosome
17
Canonical length
662 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>P16050|ALOX15
     1  MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL
    61  LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP
   121  QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK
   181  GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV
   241  LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL
   301  VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH
   361  LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST
   421  GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS
   481  LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH
   541  ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ
   601  PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV
   661  AI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALOX15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.21
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 35 nTPM
  • fallopian tube: 12 nTPM
  • lung: 6.2 nTPM
  • small intestine: 3.2 nTPM
  • breast: 3 nTPM
  • pituitary gland: 2.9 nTPM

Single-cell type

  • respiratory ciliated cells: 278 nCPM
  • respiratory secretory cells: 143 nCPM
  • respiratory deuterosomal cells: 121 nCPM
  • respiratory basal cells: 120 nCPM
  • mesothelial cells: 106 nCPM
  • epicardial cells: 46 nCPM

Immune cell

  • eosinophil: 608 nTPM
  • myeloid DC: 3.1 nTPM
  • plasmacytoid DC: 2.7 nTPM
  • neutrophil: 1.1 nTPM
  • total PBMC: 0.4 nTPM
  • basophil: 0.2 nTPM

Brain region

  • basal ganglia: 5.3 nTPM
  • cerebral cortex: 2.9 nTPM
  • hippocampal formation: 2.2 nTPM
  • hypothalamus: 2.2 nTPM
  • pons: 2 nTPM
  • white matter: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0
gnomAD missense Z
0.03
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALOX15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALOX15 as an antibody target. Whether an autoantibody or antibody against ALOX15 could matter depends on whether native ALOX15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALOX15 is annotated at the cell surface, where native ALOX15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ALOX15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ALOX15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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